Characterization and evaluation of PLA 3D-printed bone scaffolds reinforced with PVA braids for bone tissue engineering applications
摘要
Bone damage is often caused by aging, disease, and trauma. Larger bone injuries are difficult to heal, requiring bone tissue engineering to aid wound healing. 3D printing technology allows flexible, precise, and rapid manufacturing, allowing customized fabrication based on patient needs. This study investigated the properties of Polylactide (PLA) 3D-printed bone scaffolds/woven composite bone scaffolds for bone tissue engineering applications. These scaffolds were reinforced with Polyvinyl alcohol (PVA) braids. The performance of the 3D-printed/braiding composite bone scaffolds was characterized using SEM, morphological observations, dyeing analysis, pore diameter analysis, degradability assays, and cytotoxicity assays. This study also conducted compressive strength analysis based on the ATSM standard to investigate the effects of braids on the compressive strength of 3D-printed bone scaffolds before and after addition. The study found that the compressive strength of the 3D-printed bone scaffolds increased after the addition of the PVA braids, it could increase by up to 33.02%. Cell adhesion assay show that cells formed cellular bridges between fibers, which indicate excellent cell adhesion ability. This study demonstrates that the developed 3D-printed/braiding composite bone scaffold is a bone scaffold material with great application prospects in the field of bone tissue engineering.