<p>Additive manufacturing has completely overturned the process of manufacturing complex parts and made them a common sight in manufacturing, aerospace, healthcare, and automotive, among others. The orientation of parts in the printing process determines to a great extent how the mechanical properties, surface quality, and dimensional accuracy of the final products will be. In this article, the authors have reviewed the effect of the angles of Orientation on the quality of 3D printing parts. Since the quality of 3D printed parts depends on mechanical strength, surface finish, dimensional precision, and more, print angle or Orientation can affect these parameters adversely. The review also takes into account the recent studies where improvement of the Orientation angle was studied and measured for material usage, energy efficiency, and post-processing requirements. The paper suggests ways that new AI and other emerging technologies can be used to predict and optimize part Orientation angles to reduce material waste while increasing part quality. Moreover, the review discusses limitations of the use of Orientation in 3D printing that can cause surface defect deformation and decreased mechanical performance, and optimization strategies to tackle this problem. The industry-specific applications such as aerospace and automotive, healthcare, and large-scale manufacturing are outlined with implications of Orientation optimization. The paper then makes recommendations as to how future research in advanced modeling, AI-driven optimization, sustainability, and consideration of Orientation in multi-material and large-scale printing applications could be conducted. This study aims to contribute to further 3D printing technology development and its industrialization.</p>