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<p>Polymeric stents could represent a significant innovation in addressing the issues associated with metal-based drug-eluting stents. While the focus of research has been on bioabsorbable stents, polymeric permanent stents could be a safer alternative. Regarding to their manufacturing process, vat photopolymerization (VPP) techniques could be one of the most powerful technologies. Among all the types of VPP, the recently developed stereolithography 3D tubular (ST3DT) technology could stand out as it addresses the limitations of the traditional Cartesian approach, including speed, required resin quantity, and longitudinal lamination of the stent. This study focuses on the physicochemical stability of stents manufactured by ST3DT method, aiming to optimize printing and post-curing parameters to ensure proper polymerization and enhance biomechanical properties. The study examines how resin temperature during printing and post-curing parameters affects the curing dynamics and mechanical properties. The radial force, sterility, disinfection, and biocompatibility of the manufactured stents are evaluated, showing that stents manufactured at 40ºC and post-cured at 70ºC for 60&#xa0;min are infection-free, well-tolerated by human fibroblasts, and present a radial stiffness similar to commercial stents. The overall findings indicate that the manufactured stents could be well-suited for potential medical applications.</p>

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Analysis of printing and post-curing parameters to enhance physicochemical and biomechanical properties of polymeric stents produced by tubular vat photopolymerization

  • 期刊论文

  • 发表日期：

    2025年1月24日

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  • A. Bosch,
  • S. Ausellé-Bosch,
  • C. Ponce,
  • C. Rubio,
  • T. Puig,
  • J. Ciurana,
  • A.J. Guerra

摘要

Polymeric stents could represent a significant innovation in addressing the issues associated with metal-based drug-eluting stents. While the focus of research has been on bioabsorbable stents, polymeric permanent stents could be a safer alternative. Regarding to their manufacturing process, vat photopolymerization (VPP) techniques could be one of the most powerful technologies. Among all the types of VPP, the recently developed stereolithography 3D tubular (ST3DT) technology could stand out as it addresses the limitations of the traditional Cartesian approach, including speed, required resin quantity, and longitudinal lamination of the stent. This study focuses on the physicochemical stability of stents manufactured by ST3DT method, aiming to optimize printing and post-curing parameters to ensure proper polymerization and enhance biomechanical properties. The study examines how resin temperature during printing and post-curing parameters affects the curing dynamics and mechanical properties. The radial force, sterility, disinfection, and biocompatibility of the manufactured stents are evaluated, showing that stents manufactured at 40ºC and post-cured at 70ºC for 60 min are infection-free, well-tolerated by human fibroblasts, and present a radial stiffness similar to commercial stents. The overall findings indicate that the manufactured stents could be well-suited for potential medical applications.