Scholarlink

Purpose <p>Mesonephric adenocarcinomas (MA) and carcinosarcomas of female genital tract are rare tumors originating from mesonephric duct remnants, which mainly occur in cervix followed by ovarian hilum and broad ligament, and rarely in uterine corpus and lateral wall of vagina. The diagnosis of these tumors is challenging as they exhibit mixture of histomorphological pattern that can be confused with endometrioid, serous, clear cell carcinomas and sex cord stromal tumors of female genital tract. The application of a panel of immunohistochemical markers, which include PAX8, GATA3, TTF1, CD10 and ER, must be applied to reach a correct diagnosis while ruling out the mimickers.</p> Methods <p>Herein, we present four such rare cases with challenging diagnostic features. Molecular analysis performed in 3 cases showed the characteristic KRAS mutation.</p> Conclusion <p>Due diligence to the morphology and appropriate panel of immunohistochemical markers needed for the accurate diagnosis of MA.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Mesonephric Origin Tumors of Female Genital Tract-Carcinomas and Carcinosarcomas: Report of Four Cases

  • 期刊论文

  • 发表日期：

    2025年12月23日

查看全文
  • Meenakshi Kamboj,
  • Diksha Karki,
  • Anila Sharma,
  • Divya Bansal,
  • Anurag Mehta,
  • Himanshi Diwan,
  • Sunil Pasricha,
  • Gurudutt Gupta,
  • Garima Durga

摘要

Purpose

Mesonephric adenocarcinomas (MA) and carcinosarcomas of female genital tract are rare tumors originating from mesonephric duct remnants, which mainly occur in cervix followed by ovarian hilum and broad ligament, and rarely in uterine corpus and lateral wall of vagina. The diagnosis of these tumors is challenging as they exhibit mixture of histomorphological pattern that can be confused with endometrioid, serous, clear cell carcinomas and sex cord stromal tumors of female genital tract. The application of a panel of immunohistochemical markers, which include PAX8, GATA3, TTF1, CD10 and ER, must be applied to reach a correct diagnosis while ruling out the mimickers.

Methods

Herein, we present four such rare cases with challenging diagnostic features. Molecular analysis performed in 3 cases showed the characteristic KRAS mutation.

Conclusion

Due diligence to the morphology and appropriate panel of immunohistochemical markers needed for the accurate diagnosis of MA.