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Introduction <p>Choriocarcinoma is an undifferentiated trophoblastic tumour of highly malignant nature. It has great propensity to metastasize and thus presents with a wide range of symptoms mimicking other conditions.</p> Case report <p>A 35 years old woman, who initially presented to neurology outpatient with complains of right sided hemiparesis and imaging suggestive of intracranial hemorrhage, eventually developed profuse vaginal bleeding and was referred to gynecology department. On local examination a vaginal growth was observed, histopathology of which suggested neoplastic nature with immunohistochemistry positive for human chorionic gonadotropin. Pelvis ultrasonography revealed a hetero-echoic lesion. β human chorionic gonadotropin report of 4 lakhs IU confirmed the diagnosis of Gestational trophoblastic neoplasia. Her previous history included a missed abortion followed by multiple episodes of bleeding and evacuation. Further evaluation revealed pulmonary metastases. She was staged as FIGO stage III with score 11. This patient was treated with multi-agent chemotherapy and showed a favourable response, achieving complete remission.</p> Conclusion <p>This case highlights the importance of early diagnosis as timely identification significantly impacts prognosis. A high index of suspicion is essential, especially in atypical presentations.</p>

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Gestational Choriocarcinoma: An Elusive Malignancy

  • 期刊论文

  • 发表日期：

    2025年9月18日

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  • Ankita Kumari,
  • Chetna A. Sethi,
  • Sangeeta Gupta,
  • Reena Tomar,
  • Rahul Kumar

摘要

Introduction

Choriocarcinoma is an undifferentiated trophoblastic tumour of highly malignant nature. It has great propensity to metastasize and thus presents with a wide range of symptoms mimicking other conditions.

Case report

A 35 years old woman, who initially presented to neurology outpatient with complains of right sided hemiparesis and imaging suggestive of intracranial hemorrhage, eventually developed profuse vaginal bleeding and was referred to gynecology department. On local examination a vaginal growth was observed, histopathology of which suggested neoplastic nature with immunohistochemistry positive for human chorionic gonadotropin. Pelvis ultrasonography revealed a hetero-echoic lesion. β human chorionic gonadotropin report of 4 lakhs IU confirmed the diagnosis of Gestational trophoblastic neoplasia. Her previous history included a missed abortion followed by multiple episodes of bleeding and evacuation. Further evaluation revealed pulmonary metastases. She was staged as FIGO stage III with score 11. This patient was treated with multi-agent chemotherapy and showed a favourable response, achieving complete remission.

Conclusion

This case highlights the importance of early diagnosis as timely identification significantly impacts prognosis. A high index of suspicion is essential, especially in atypical presentations.