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Purpose <p>Role of magnetic resonance (MR) perfusion study: quantitative and semi-quantitative analysis in differentiation of benign and malignant adnexal masses.</p> Materials and Methods <p>MR perfusion was performed on fifty pathologically proven benign and malignant adnexal masses on a 3&#xa0;T MRI scanner. The perfusion parameters were defined as quantitative parameters—volume transfer constant (K trans), rate constant (K ep), fraction of plasma volume (V p), and semi-quantitative parameters—maximum signal intensity over time (SI max), relative signal intensity (SI rel), end signal intensity (SI end), time to peak (TTP), wash-in rate (WIR), and wash-out rate (WOR). Statistical analysis was done to study the association between these perfusion parameters and histopathological diagnosis.</p> Results <p>The study comprised 25 pathologically confirmed malignant and 25 benign adnexal masses. The mean K trans, K ep and SI end values were elevated in malignant masses and showed statistically significant association (<i>p</i> value &lt; 0.05), among which K trans had the highest diagnostic merit (<i>p</i> value 0.001, diagnostic accuracy 78%, sensitivity 92% and specificity 64%). However, the rest of the parameters did not show a statistically significant association.</p> Conclusion <p>MR perfusion revealed statistically significantly higher values of K trans, K ep and SI end values in malignant adnexal masses as compared to the benign ones. Thus, MR perfusion is a relevant and useful tool in the differentiation of benign and malignant adnexal masses.</p> <p>Clinical Relevance.</p> <p>Adnexal masses are a remarkably heterogeneous group that poses a dramatic challenge to radiologists, surgeons, and pathologists for diagnosis. The clinical impact of predicting the likelihood of malignancy is crucial for proper patient management. MR perfusion is based on a dynamic study of tumour microvasculature; hence, it provides anatomical as well as functional assessment of complex adnexal masses with substantial diagnostic utility.</p>

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Diagnostic Efficacy of MR Perfusion: Quantitative and Semi-Quantitative Analysis in the Differentiation of Benign and Malignant Adnexal Masses

  • 期刊论文

  • 发表日期：

    2025年9月17日

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  • Namrata Bagchi,
  • Neha Bagri,
  • Ritu Misra,
  • Saritha Shamsunder,
  • Charanjeet Ahluwalia

摘要

Purpose

Role of magnetic resonance (MR) perfusion study: quantitative and semi-quantitative analysis in differentiation of benign and malignant adnexal masses.

Materials and Methods

MR perfusion was performed on fifty pathologically proven benign and malignant adnexal masses on a 3 T MRI scanner. The perfusion parameters were defined as quantitative parameters—volume transfer constant (K trans), rate constant (K ep), fraction of plasma volume (V p), and semi-quantitative parameters—maximum signal intensity over time (SI max), relative signal intensity (SI rel), end signal intensity (SI end), time to peak (TTP), wash-in rate (WIR), and wash-out rate (WOR). Statistical analysis was done to study the association between these perfusion parameters and histopathological diagnosis.

Results

The study comprised 25 pathologically confirmed malignant and 25 benign adnexal masses. The mean K trans, K ep and SI end values were elevated in malignant masses and showed statistically significant association (p value < 0.05), among which K trans had the highest diagnostic merit (p value 0.001, diagnostic accuracy 78%, sensitivity 92% and specificity 64%). However, the rest of the parameters did not show a statistically significant association.

Conclusion

MR perfusion revealed statistically significantly higher values of K trans, K ep and SI end values in malignant adnexal masses as compared to the benign ones. Thus, MR perfusion is a relevant and useful tool in the differentiation of benign and malignant adnexal masses.

Clinical Relevance.

Adnexal masses are a remarkably heterogeneous group that poses a dramatic challenge to radiologists, surgeons, and pathologists for diagnosis. The clinical impact of predicting the likelihood of malignancy is crucial for proper patient management. MR perfusion is based on a dynamic study of tumour microvasculature; hence, it provides anatomical as well as functional assessment of complex adnexal masses with substantial diagnostic utility.