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Background <p>The treatment of cervical cancer frequently includes the use of brachytherapy combined with external beam radiotherapy (EBRT). Uterine anomalies, including septate, bicornuate, or didelphic uteri, pose considerable challenges to conventional brachytherapy methods, complicating applicator placement, dose distribution, and imaging processes.</p> Methods <p>This review analysed existing literature and case reports related to the application of brachytherapy in patients diagnosed with cervical cancer and uterine anomalies.</p> Results <p>Frequently observed uterine anomalies comprised uterus didelphys, bicornuate uterus, and septate uterus. The observed anomalies modified the standard applicator geometry, resulting in challenges related to dose distribution and the protection of organs at risk (OAR).</p> Conclusion <p>Application of brachytherapy for patients with uterine anomalies necessitates tailored treatment approaches. The implementation of MRI-based planning, the utilization of hybrid applicators, and the adoption of adaptive techniques, including 3D printed applicators, have the potential to enhance therapeutic outcomes.</p>

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Navigating Anatomical Challenges in Brachytherapy in Cervical Cancer Patients with Uterine Anomalies: A Narrative Review

  • 期刊论文

  • 发表日期：

    2025年8月11日

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  • Pooja Kalra,
  • Sweety Gupta,
  • Shivam Kumar,
  • Deepika Raina

摘要

Background

The treatment of cervical cancer frequently includes the use of brachytherapy combined with external beam radiotherapy (EBRT). Uterine anomalies, including septate, bicornuate, or didelphic uteri, pose considerable challenges to conventional brachytherapy methods, complicating applicator placement, dose distribution, and imaging processes.

Methods

This review analysed existing literature and case reports related to the application of brachytherapy in patients diagnosed with cervical cancer and uterine anomalies.

Results

Frequently observed uterine anomalies comprised uterus didelphys, bicornuate uterus, and septate uterus. The observed anomalies modified the standard applicator geometry, resulting in challenges related to dose distribution and the protection of organs at risk (OAR).

Conclusion

Application of brachytherapy for patients with uterine anomalies necessitates tailored treatment approaches. The implementation of MRI-based planning, the utilization of hybrid applicators, and the adoption of adaptive techniques, including 3D printed applicators, have the potential to enhance therapeutic outcomes.