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Introduction and Background <p>Primary hepatoid adenocarcinoma of the peritoneum (PHAP) is a rare but important subtype of extrahepatic adenocarcinoma, often mistaken for hepatocellular carcinoma (HCC), which makes diagnosis and treatment optimization challenging. To date, hepatoid adenocarcinoma of primary peritoneal origin has been reported only in case studies, limiting the data on managing its distinct behavior.</p> Discussion <p>Accurate diagnosis of PHAP is critical for prognosis. PHAP should be considered in middle-aged or elderly patients presenting with elevated serum alpha-fetoprotein (AFP) levels and atypical hepatic imaging findings. Immunohistochemical staining is key to differentiating PHAP from HCC.</p> Conclusion <p>PHAP is a rare and aggressive disease with significant diagnostic and therapeutic challenges. A multidisciplinary approach is essential for accurate diagnosis and management. More data are needed to establish standardized treatment protocols.</p>

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Primary Peritoneal Hepatoid Adenocarcinoma: A Multidisciplinary Approach for a Rare Case Scenario

  • 期刊论文

  • 发表日期：

    2025年5月23日

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  • Mahmoud A. Elseadany,
  • Fatmaelzahraa Abdelfattah Denewar,
  • Reham Mohamed Nagib,
  • Raghda Tarek

摘要

Introduction and Background

Primary hepatoid adenocarcinoma of the peritoneum (PHAP) is a rare but important subtype of extrahepatic adenocarcinoma, often mistaken for hepatocellular carcinoma (HCC), which makes diagnosis and treatment optimization challenging. To date, hepatoid adenocarcinoma of primary peritoneal origin has been reported only in case studies, limiting the data on managing its distinct behavior.

Discussion

Accurate diagnosis of PHAP is critical for prognosis. PHAP should be considered in middle-aged or elderly patients presenting with elevated serum alpha-fetoprotein (AFP) levels and atypical hepatic imaging findings. Immunohistochemical staining is key to differentiating PHAP from HCC.

Conclusion

PHAP is a rare and aggressive disease with significant diagnostic and therapeutic challenges. A multidisciplinary approach is essential for accurate diagnosis and management. More data are needed to establish standardized treatment protocols.