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Background <p>The occurrence of primary fallopian tube carcinoma (PFTC) is infrequent, with an estimated incidence ranging from 0.1 to 1.8% of all gynecological neoplasms. Clinically and histologically, PFTC resembles ovarian carcinomas. We present a bilateral PFTC which was mistaken for an endometrial carcinoma and attempt to elaborate its clinical and histomorphological features.</p> Case Presentation <p>A postmenopausal 60-year-old woman reported vaginal bleeding for 2 months. The external institute magnetic resonance imaging suggested a stage 1, endometrial carcinoma. Laboratory work-up showed an elevated CA-125 level (117&#xa0;U/ml). Endometrial biopsy revealed moderately differentiated, endometroid endometrial adenocarcinoma. The histopathological evaluation and immunohistochemistry of the resection specimen received in our institute revealed a high-grade serous adenocarcinoma, arising in bilateral fallopian tubes and secondary involvement of the endometrium, FIGO stage IIA. The patient received six cycles of chemotherapy. Twelve months after the initial surgery, the patient is alive and symptom-free.</p> Conclusion <p>PFTC is a rare gynecological malignancy that should be considered in the differential diagnosis for a postmenopausal woman presenting with vaginal bleeding, irrespective of the endometrial curettage findings.</p>

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Unusual Presentation of Bilateral Primary Fallopian Tube Carcinoma

  • 期刊论文

  • 发表日期：

    2025年1月21日

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  • Rahul Rajbhar,
  • Sujata Chaudhary,
  • Ashvini Kolhe

摘要

Background

The occurrence of primary fallopian tube carcinoma (PFTC) is infrequent, with an estimated incidence ranging from 0.1 to 1.8% of all gynecological neoplasms. Clinically and histologically, PFTC resembles ovarian carcinomas. We present a bilateral PFTC which was mistaken for an endometrial carcinoma and attempt to elaborate its clinical and histomorphological features.

Case Presentation

A postmenopausal 60-year-old woman reported vaginal bleeding for 2 months. The external institute magnetic resonance imaging suggested a stage 1, endometrial carcinoma. Laboratory work-up showed an elevated CA-125 level (117 U/ml). Endometrial biopsy revealed moderately differentiated, endometroid endometrial adenocarcinoma. The histopathological evaluation and immunohistochemistry of the resection specimen received in our institute revealed a high-grade serous adenocarcinoma, arising in bilateral fallopian tubes and secondary involvement of the endometrium, FIGO stage IIA. The patient received six cycles of chemotherapy. Twelve months after the initial surgery, the patient is alive and symptom-free.

Conclusion

PFTC is a rare gynecological malignancy that should be considered in the differential diagnosis for a postmenopausal woman presenting with vaginal bleeding, irrespective of the endometrial curettage findings.