The Role of Long Noncoding RNAs (LncRNAs) in the Pathogenesis of Chemoresistance in Endometrial Cancer: A Molecular Approach and Future Perspective

Endometrial cancer (EC) is one of the common diseases that affects women. In an advanced state, malignant cells become resistant to chemotherapy, reducing patients' survival. Long noncoding RNAs (LncRNAs) are one of the factors contributing to chemotherapy resistance. This review investigates the role of LncRNAs in the processes of proliferation, apoptosis, angiogenesis, and epithelial–mesenchymal transition (EMT).

In this review study, the article with English language was selected for writing the manuscript. Also, the PubMed database was used for search.

LncRNAs cause chemoresistance by regulating genes and molecular pathways. These genes and pathways are mainly involved in the processes of apoptosis, proliferation, EMT, and angiogenesis. These processes cause the insensitivity of malignant cells to chemotherapy drugs and the occurrence of chemoresistance.

Given the dual role of some LncRNAs, identifying the pathways associated with LncRNAs, as well as their UP and Downstream factors can be effective in designing targeted therapies such as personalizing medicine.