Purpose <p>Cleft lip and/or palate (CLP) is among the most common congenital anomalies, occurring in approximately 1 out of 700 live births globally, with varying severity and anatomical complications. Cleft patients encounter several difficulties, including speech, feeding, and maxillary growth impairment, primarily caused by scar formation after early-age surgical interventions. This article aims to guide future research and clinical practice to enhance the quality of life for individuals affected by clefts.</p> Methods <p>This review explores the anatomy of the cleft-affected lip and palate, the pathophysiology of scar-induced growth disturbances, and the latest regenerative strategies aimed at reducing scarring.</p> Results <p>While traditional surgical techniques have evolved to minimize scarring, the potential of these methods is inherently limited in addressing soft tissue regeneration. Regenerative medicine offers innovative solutions to attenuate scar formation and promote tissue regeneration by integrating stem cell therapy, tissue engineering, biomaterial scaffolds, and genetic modification. However, challenges such as optimizing scaffold properties, enhancing long-term integration with native tissues, tackling immune responses, and addressing safety concerns remain significant obstacles to clinical translation.</p> Conclusion <p>By integrating regenerative techniques with surgical procedures, these approaches hold the potential to revolutionize outcomes for CLP patients, improving both functional and aesthetic rehabilitation.</p> Graphical Abstract <p></p>