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Purpose <p>Wound healing presents a significant challenge in healthcare, traditional dressings often fail to provide optimal healing environments. Nanocellulose-based hydrogels have emerged as promising solutions for wound healing due to their excellent water retention, biocompatibility, and mechanical strength.</p> Methods <p>We conducted a comprehensive review of different types of nanocellulose including cellulose nanofibrils (CNF), cellulose nanocrystals (CNC), bacterial nanocellulose (BNC), and tunicate nanocellulose (TNC) analyzing their structural properties through in vitro and in vivo wound healing studies.</p> Results <p>This review highlights the recent advancements in nanocellulose-based hydrogels, focusing on their structural properties, in vitro and in vivo wound healing studies, and potential for clinical translation. The results highlight the improved moisture retention ability of CNF-based hydrogels, CNC reinforcement ability, and the suitability of BNC membranes for moist wound healing. Despite promising developments, scalability of production and standardization of characterization protocols are limited and understanding of degradation kinetics remains a challenge to be overcome.</p> Conclusion <p>Future studies should aim at developing affordable large-scale production techniques, integrating antimicrobial and anti-inflammatory qualities, and optimizing nanocellulose formulations for various wound types. By overcoming these challenges, nanocellulose-based hydrogels will accelerate the transition from lab studies to clinical uses, providing advanced and long-lasting wound care solutions.</p> Lay Summary <p>Nanocellulose-based hydrogels offer advanced solutions for wound healing challenges. These materials combine excellent water retention, biocompatibility, and mechanical strength to create ideal wound-healing environments. Various types of nanocellulose provide unique benefits: CNF enhances moisture retention, CNC improves structural integrity, and BNC creates effective moist healing membranes. While current research shows promising results in laboratory and animal studies, challenges in production scaling and standardization need to be addressed before widespread clinical use. Overcoming these barriers will lead to advanced, long-lasting wound care solutions that significantly improve patient outcomes compared to traditional dressings.</p> Graphical Abstract <p></p>

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Nanocellulose-based Hydrogels in Wound Healing: Innovations, Challenges, and Future Prospects for Clinical Translation

  • 期刊论文

  • 发表日期：

    2026年5月29日

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  • Karuppan Perumal Manoj Kumar,
  • Remya Rajan Renuka,
  • Suresh Kumar Subbiah

摘要

Purpose

Wound healing presents a significant challenge in healthcare, traditional dressings often fail to provide optimal healing environments. Nanocellulose-based hydrogels have emerged as promising solutions for wound healing due to their excellent water retention, biocompatibility, and mechanical strength.

Methods

We conducted a comprehensive review of different types of nanocellulose including cellulose nanofibrils (CNF), cellulose nanocrystals (CNC), bacterial nanocellulose (BNC), and tunicate nanocellulose (TNC) analyzing their structural properties through in vitro and in vivo wound healing studies.

Results

This review highlights the recent advancements in nanocellulose-based hydrogels, focusing on their structural properties, in vitro and in vivo wound healing studies, and potential for clinical translation. The results highlight the improved moisture retention ability of CNF-based hydrogels, CNC reinforcement ability, and the suitability of BNC membranes for moist wound healing. Despite promising developments, scalability of production and standardization of characterization protocols are limited and understanding of degradation kinetics remains a challenge to be overcome.

Conclusion

Future studies should aim at developing affordable large-scale production techniques, integrating antimicrobial and anti-inflammatory qualities, and optimizing nanocellulose formulations for various wound types. By overcoming these challenges, nanocellulose-based hydrogels will accelerate the transition from lab studies to clinical uses, providing advanced and long-lasting wound care solutions.

Lay Summary

Nanocellulose-based hydrogels offer advanced solutions for wound healing challenges. These materials combine excellent water retention, biocompatibility, and mechanical strength to create ideal wound-healing environments. Various types of nanocellulose provide unique benefits: CNF enhances moisture retention, CNC improves structural integrity, and BNC creates effective moist healing membranes. While current research shows promising results in laboratory and animal studies, challenges in production scaling and standardization need to be addressed before widespread clinical use. Overcoming these barriers will lead to advanced, long-lasting wound care solutions that significantly improve patient outcomes compared to traditional dressings.

Graphical Abstract