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<p>Lung organoids are three-dimensional structures made from stem cells that mimic important parts of the respiratory system. They have become important tools for studying lung biology and disease. This review delves into the most recent progress in developing and using lung organoids to model a wide range of lung diseases, such as genetic disorders, infections, fibrosis, acute lung injury, and cancer. The lung organoids can be combined with cutting-edge technologies like CRISPR-Cas9, single-cell transcriptomics, and multi-omics analyses. These technologies have made lung organoids much more useful for understanding the mechanisms of diseases, the interaction of pathogens with hosts, and the response of the immune system. Also, lung organoids are being used more and more for drug screening, personalized medicine, and regenerative therapies. Despite the potential of lung organoids, their effective utilization may still face challenges, such as the absence of different cell types, the lack of blood vessels or immune cells, and inconsistency in their production. The review also explores the possible strategies to deal with these challenges, including co-culture systems, bioengineering methods, etc. Lung organoids are a powerful and flexible platform that is changing the way respiratory diseases are modelled and assisting in developing new treatments.</p>

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Advances in Stem Cell-Derived Organoids for Treating and Understanding Lung Diseases

  • 期刊论文

  • 发表日期：

    2026年2月6日

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  • Nikita Raut,
  • Himanshu Paliwal,
  • Bhupendra G. Prajapati,
  • Sharav Desai,
  • Vipul P. Patel

摘要

Lung organoids are three-dimensional structures made from stem cells that mimic important parts of the respiratory system. They have become important tools for studying lung biology and disease. This review delves into the most recent progress in developing and using lung organoids to model a wide range of lung diseases, such as genetic disorders, infections, fibrosis, acute lung injury, and cancer. The lung organoids can be combined with cutting-edge technologies like CRISPR-Cas9, single-cell transcriptomics, and multi-omics analyses. These technologies have made lung organoids much more useful for understanding the mechanisms of diseases, the interaction of pathogens with hosts, and the response of the immune system. Also, lung organoids are being used more and more for drug screening, personalized medicine, and regenerative therapies. Despite the potential of lung organoids, their effective utilization may still face challenges, such as the absence of different cell types, the lack of blood vessels or immune cells, and inconsistency in their production. The review also explores the possible strategies to deal with these challenges, including co-culture systems, bioengineering methods, etc. Lung organoids are a powerful and flexible platform that is changing the way respiratory diseases are modelled and assisting in developing new treatments.