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Purpose <p>Gangrene, marked by tissue necrosis resulting from infection or inadequate blood supply, poses a major clinical challenge with high morbidity and amputation rates. Conventional treatments often fail to regenerate tissue or address patient-specific factors. This review investigates the role of personalized medicine in advancing gangrene management by integrating genomics, regenerative therapies, and targeted interventions.</p> Methods <p>This narrative review synthesizes recent clinical trials, preclinical studies, and translational research related to personalized gangrene therapies. Key areas of focus include genomic profiling, stem cell therapies, gene editing (e.g., CRISPR-Cas9), tissue engineering, biomarker-based diagnostics, and individualized antimicrobial regimens. Data were obtained from PubMed, ClinicalTrials.gov, and leading biotechnology publications.</p> Results <p>Emerging approaches in personalized medicine show promise in transforming gangrene care. Genomic and biomarker-driven strategies enable early diagnosis and tailored therapy. Stem cell-based regenerative therapies and bioengineered tissue constructs promote tissue repair. Gene editing technologies offer potential for correcting underlying molecular dysfunctions. Precision vascular interventions and customized drug delivery systems enhance therapeutic targeting. Though challenges remain in clinical translation and scalability, interdisciplinary innovations are rapidly advancing toward individualized gangrene treatment.</p> Conclusion <p>Personalized medicine offers a transformative pathway in gangrene management by shifting from generalized to patient-specific therapies. Integration of genomics, regenerative technologies, and precision diagnostics can improve healing outcomes, reduce amputations, and address the underlying pathology. Continued research and collaboration across disciplines are essential to overcome current limitations and realize the full potential of individualized treatment strategies.</p> Lay Summary <p>Gangrene is a serious condition where body tissues die due to poor blood flow or infection. Current treatments often involve surgery and antibiotics, but they may not heal the tissue or prevent further damage. Personalized medicine is a new way to treat gangrene by customizing care based on each person’s unique genetic and medical profile. This review looks at advanced approaches like stem cell therapy, gene editing, and custom antibiotics to improve healing. It also explores technologies that help doctors find the best treatment for each patient. Personalized care may lead to better results, fewer amputations, and new hope for people with gangrene.</p>

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Advancing Gangrene Treatment: Integrating Regenerative Medicine and Bioengineering Approaches

  • 期刊论文

  • 发表日期：

    2026年1月21日

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  • Pavithra Bharathy,
  • Shakthi Harikrishnan,
  • Jagadeesh Chandrasekar,
  • Priya Modhugur Sathyanarayanan,
  • Binoy Varghese Cheriyan

摘要

Purpose

Gangrene, marked by tissue necrosis resulting from infection or inadequate blood supply, poses a major clinical challenge with high morbidity and amputation rates. Conventional treatments often fail to regenerate tissue or address patient-specific factors. This review investigates the role of personalized medicine in advancing gangrene management by integrating genomics, regenerative therapies, and targeted interventions.

Methods

This narrative review synthesizes recent clinical trials, preclinical studies, and translational research related to personalized gangrene therapies. Key areas of focus include genomic profiling, stem cell therapies, gene editing (e.g., CRISPR-Cas9), tissue engineering, biomarker-based diagnostics, and individualized antimicrobial regimens. Data were obtained from PubMed, ClinicalTrials.gov, and leading biotechnology publications.

Results

Emerging approaches in personalized medicine show promise in transforming gangrene care. Genomic and biomarker-driven strategies enable early diagnosis and tailored therapy. Stem cell-based regenerative therapies and bioengineered tissue constructs promote tissue repair. Gene editing technologies offer potential for correcting underlying molecular dysfunctions. Precision vascular interventions and customized drug delivery systems enhance therapeutic targeting. Though challenges remain in clinical translation and scalability, interdisciplinary innovations are rapidly advancing toward individualized gangrene treatment.

Conclusion

Personalized medicine offers a transformative pathway in gangrene management by shifting from generalized to patient-specific therapies. Integration of genomics, regenerative technologies, and precision diagnostics can improve healing outcomes, reduce amputations, and address the underlying pathology. Continued research and collaboration across disciplines are essential to overcome current limitations and realize the full potential of individualized treatment strategies.

Lay Summary

Gangrene is a serious condition where body tissues die due to poor blood flow or infection. Current treatments often involve surgery and antibiotics, but they may not heal the tissue or prevent further damage. Personalized medicine is a new way to treat gangrene by customizing care based on each person’s unique genetic and medical profile. This review looks at advanced approaches like stem cell therapy, gene editing, and custom antibiotics to improve healing. It also explores technologies that help doctors find the best treatment for each patient. Personalized care may lead to better results, fewer amputations, and new hope for people with gangrene.