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Abstract <p>Angiogenes is the term used to denote the formation of new blood capillaries from the pre-existing blood vessels. It is an important process during tissue repair and regeneration, but excessive angiogenesis can result in tumor formation. Tumor tissues are characterized by quick proliferation, rapid metabolism and increased requirement of oxygen and nutrients. Tumor angiogenesis serves as one of the most important stages of cancer progression. Suppression of angiogenic factors will play a significant role in treating diseases that are caused due to uncontrolled vascularization. Vascular endothelial growth factor (VEGF)/VEGF receptor 2 signaling pathway is recognized as the most crucial factor that is involved in controlling almost all phases of physiological angiogenesis. Angiogenic inhibitors inhibit different growth factors and receptors that play crucial role in inducing angiogenesis. This review gives information about angiogenesis, its mechanism and various growth factors that are involved in the process. The different inhibitors of angiogenesis and the role of anti-angiogenic therapy in cancer treatment are also discussed.</p> Lay Summary <p>Angiogenesis is a multifaceted biological process that is crucial for the regeneration of tissues and organs. Tumor angiogenesis is one of the extremely important steps in cancer progression. Inhibitors based on monoclonal antibody are widely used in anti-angiogenic therapy.</p>

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A Mini-review On Angiogenesis and Its Role in Cancer

  • 期刊论文

  • 发表日期：

    2025年10月2日

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  • Hakshaya Pushpendran,
  • Yovan Raja Pravin,
  • Ramsana Rahim,
  • Shangavy Pandiarajan,
  • Sathyaraj Weslen Vedakumari

摘要

Abstract

Angiogenes is the term used to denote the formation of new blood capillaries from the pre-existing blood vessels. It is an important process during tissue repair and regeneration, but excessive angiogenesis can result in tumor formation. Tumor tissues are characterized by quick proliferation, rapid metabolism and increased requirement of oxygen and nutrients. Tumor angiogenesis serves as one of the most important stages of cancer progression. Suppression of angiogenic factors will play a significant role in treating diseases that are caused due to uncontrolled vascularization. Vascular endothelial growth factor (VEGF)/VEGF receptor 2 signaling pathway is recognized as the most crucial factor that is involved in controlling almost all phases of physiological angiogenesis. Angiogenic inhibitors inhibit different growth factors and receptors that play crucial role in inducing angiogenesis. This review gives information about angiogenesis, its mechanism and various growth factors that are involved in the process. The different inhibitors of angiogenesis and the role of anti-angiogenic therapy in cancer treatment are also discussed.

Lay Summary

Angiogenesis is a multifaceted biological process that is crucial for the regeneration of tissues and organs. Tumor angiogenesis is one of the extremely important steps in cancer progression. Inhibitors based on monoclonal antibody are widely used in anti-angiogenic therapy.