Scholarlink

Abstract <p>Diabetic wounds&#xa0;(DW) are characterized by impaired healing due to impaired angiogenesis and reduced formation of critical extracellular matrix components like collagen, resulting from prolonged inflammatory phases. The pro-inflammatory environment results from M1 macrophage polarization, which causes the depletion of various pro-angiogenic molecules in the extracellular matrix like Vascular Endothelial Growth Factor (VEGF) while increasing inflammatory mediators like Interleukin-1beta (IL-1β) and Tumor Necrosis Factor-alpha&#xa0;(TNF-α). Multiple types of&#xa0;Decellularized Extracellular Matrices (dECM), like Dermaglide and OASIS, have recently been commercialized owing to their tremendous regenerative capabilities in different preclinical and clinical studies in diabetic ulcer therapy. The natural ECM houses vital matricellular proteins and signalling molecules that play essential regenerative and therapeutic roles. This article will try to cover critical aspects of dECM-based therapies for diabetic wound therapy. This review will highlight the potential of dECM-based therapy to counter various aspects of diabetic wounding, like inflammation and lack of angiogenesis. Finally, the review will discuss in detail different fabricated scaffolds and uncover the potential of dECM as a delivery vehicle for diabetic ulcer therapy. This review will also highlight the clinical application of dECM scaffolds in diabetic ulcer therapy.</p> Lay Summary <p>Diabetic wounds are typical hypoxic wounds characterized by a prolonged inflammatory phase, which can slowly progress to sepsis, and&#xa0;leading to amputation. Decellularized extracellular matrices have emerged as game-changing materials in regenerative medicine due to collagen, alongside glycosaminoglycans (GAG), and other biomacromolecules. The article establishes the therapeutic role of dECM in the pathophysiology of diabetic wounds. In this article, an exclusive focus has been given to different dECM-based bioengineered scaffolds in diabetic ulcer therapy and their fabrication techniques. Finally, the article highlights the importance of dECM scaffolds as therapeutic delivery vehicles and their role in the clinical setup.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bioengineered Decellularized Extracellular Matrices in Diabetic Ulcer Therapy: Therapeutic and Clinical Outlook

  • 期刊论文

  • 发表日期：

    2025年10月31日

查看全文
  • Teeshyo Bhattacharya,
  • Avijit Bej,
  • Anwesha Das,
  • Shubham Singh Bartwal,
  • Arijit Nandi

摘要

Abstract

Diabetic wounds (DW) are characterized by impaired healing due to impaired angiogenesis and reduced formation of critical extracellular matrix components like collagen, resulting from prolonged inflammatory phases. The pro-inflammatory environment results from M1 macrophage polarization, which causes the depletion of various pro-angiogenic molecules in the extracellular matrix like Vascular Endothelial Growth Factor (VEGF) while increasing inflammatory mediators like Interleukin-1beta (IL-1β) and Tumor Necrosis Factor-alpha (TNF-α). Multiple types of Decellularized Extracellular Matrices (dECM), like Dermaglide and OASIS, have recently been commercialized owing to their tremendous regenerative capabilities in different preclinical and clinical studies in diabetic ulcer therapy. The natural ECM houses vital matricellular proteins and signalling molecules that play essential regenerative and therapeutic roles. This article will try to cover critical aspects of dECM-based therapies for diabetic wound therapy. This review will highlight the potential of dECM-based therapy to counter various aspects of diabetic wounding, like inflammation and lack of angiogenesis. Finally, the review will discuss in detail different fabricated scaffolds and uncover the potential of dECM as a delivery vehicle for diabetic ulcer therapy. This review will also highlight the clinical application of dECM scaffolds in diabetic ulcer therapy.

Lay Summary

Diabetic wounds are typical hypoxic wounds characterized by a prolonged inflammatory phase, which can slowly progress to sepsis, and leading to amputation. Decellularized extracellular matrices have emerged as game-changing materials in regenerative medicine due to collagen, alongside glycosaminoglycans (GAG), and other biomacromolecules. The article establishes the therapeutic role of dECM in the pathophysiology of diabetic wounds. In this article, an exclusive focus has been given to different dECM-based bioengineered scaffolds in diabetic ulcer therapy and their fabrication techniques. Finally, the article highlights the importance of dECM scaffolds as therapeutic delivery vehicles and their role in the clinical setup.

Graphical Abstract