Abstract <p>In the majority of affluent nations, colorectal cancer is the primary cause of illness and death. Effective cancer treatment is a major worldwide problem these days, and new developments in nanomedicine are essential. The use of natural bioactive substances in nanotechnology’s quickly developing delivery methods for site-specific disease treatment is attracting a lot of interest. A relatively new and extremely interesting field of cancer treatment is the combination of nanotechnology with bioactives. Apart from their nutritional advantages, natural bioactive chemicals may also be used as a chemotherapeutic agent to treat cancer. Therapeutics has been successfully delivered to a specific spot using a variety of biopolymers.</p> Lay Summary <p>Biopolymeric nanoparticles have drawn a lot of interest in the creation of novel anticancer drug delivery methods due to their biodegradability. Through comparison reading, readers may identify appropriate solutions in this sector and gain an understanding of the features of different biopolymers in addition to the present development status of nano anticancer drug delivery systems based on biopolymers.</p> Graphical Abstract <p></p>