Abstract <p>Cell-mediated drug delivery is considered a promising therapeutic strategy designed to increase the efficacy of pharmacological materials and minimize their toxicity. This review demonstrates the potential use of different cells such as erythrocytes, platelets, immune cells, and stem cells as delivery systems for different pharmacological drugs, such as chemotherapeutic drugs, into their final destination within the body by discussing their main properties and features that make them suitable to be used as drug delivery systems, in addition to their role in overcoming all the challenges associated with the conventional drug delivery methods, such as their retention time and bioavailability. Hence, this review intends to provide valuable insights into the probable applications and implications of cell-mediated drug delivery in improving therapeutic outcomes in various clinical settings. Lay Summary. Cell-mediated drug delivery is a novel strategy to increase medication efficacy while lowering negative side effects. This article summarizes how different cell types—including red blood cells, platelets, immune cells, and stem cells—can be employed to deliver medications, such as chemotherapy treatments, to particular body parts. The review emphasizes the special qualities of these cells that make them perfect for drug administration, including their capacity to get around frequent problems with conventional techniques, such as making sure the drug remains in the body for a sufficient amount of time and enhancing absorption. The review’s overall goal is to offer insightful information on how cell-mediated drug delivery might improve therapy results in many medical scenarios.</p> Lay Summary <p>Cell-mediated drug delivery is a novel strategy to increase medication efficacy while lowering negative side effects. This article summarizes how different cell types—including red blood cells, platelets, immune cells, and stem cells—can be employed to deliver medications, such as chemotherapy treatments, to particular body parts. The review emphasizes the special qualities of these cells that make them perfect for drug administration, including their capacity to get around frequent problems with conventional techniques, such as making sure the drug remains in the body for a sufficient amount of time and enhancing absorption. The review's’s overall goal is to offer insightful information on how cell-mediated drug delivery might improve therapy results in many medical scenarios.</p>

Innovative Approaches in Drug Delivery: Cell-Mediated Drug Delivery

期刊论文
发表日期：

2025年9月2日

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Duaa Abuarqoub,
Mais Emad

摘要

Abstract

Cell-mediated drug delivery is considered a promising therapeutic strategy designed to increase the efficacy of pharmacological materials and minimize their toxicity. This review demonstrates the potential use of different cells such as erythrocytes, platelets, immune cells, and stem cells as delivery systems for different pharmacological drugs, such as chemotherapeutic drugs, into their final destination within the body by discussing their main properties and features that make them suitable to be used as drug delivery systems, in addition to their role in overcoming all the challenges associated with the conventional drug delivery methods, such as their retention time and bioavailability. Hence, this review intends to provide valuable insights into the probable applications and implications of cell-mediated drug delivery in improving therapeutic outcomes in various clinical settings. Lay Summary. Cell-mediated drug delivery is a novel strategy to increase medication efficacy while lowering negative side effects. This article summarizes how different cell types—including red blood cells, platelets, immune cells, and stem cells—can be employed to deliver medications, such as chemotherapy treatments, to particular body parts. The review emphasizes the special qualities of these cells that make them perfect for drug administration, including their capacity to get around frequent problems with conventional techniques, such as making sure the drug remains in the body for a sufficient amount of time and enhancing absorption. The review’s overall goal is to offer insightful information on how cell-mediated drug delivery might improve therapy results in many medical scenarios.

Lay Summary

Cell-mediated drug delivery is a novel strategy to increase medication efficacy while lowering negative side effects. This article summarizes how different cell types—including red blood cells, platelets, immune cells, and stem cells—can be employed to deliver medications, such as chemotherapy treatments, to particular body parts. The review emphasizes the special qualities of these cells that make them perfect for drug administration, including their capacity to get around frequent problems with conventional techniques, such as making sure the drug remains in the body for a sufficient amount of time and enhancing absorption. The review's’s overall goal is to offer insightful information on how cell-mediated drug delivery might improve therapy results in many medical scenarios.