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Abstract <p>Silk sericin, a natural biomaterial composed of 18 amino acids, possesses diverse biological properties such as water solubility, UV resistant activity, biocompatibility, non-cytotoxicity and moisturizing ability. Moreover, this protein has antioxidant, anti-inflammatory and regenerative potential. With the latest developments, the sericin-based microcapsules, hydrogels, nanoparticles, scaffolds and other biomaterials have been developed by combining sericin with different synthetic polymers. Sericin microcapsules (including microspheres and micro-particles) have complex features and are used in drug delivery, regenerative medicines, wound healing, nutraceuticals and many other applications. All these features of sericin make it a favorable polymer as it has potential in biomedicine as therapeutic as well as drug delivery agent. In this review, the important properties and biomedical applications of sericin microcapsules in biomedicine, tissue engineering, drug delivery, cosmetics and pharmacological industries are discussed.</p> Lay Summary <p>The biomedical research is now focused on unfolding the biological potential of natural protein polymers and the development of novel drug delivery agents. Sericin is a natural protein that has vast biologicals potentials including regenerative, antioxidant, anti-inflammatory and antidiabetic potentials as well as can be used in the production of novel drug delivery agents including scaffolds, hydrogels, microparticles, liposomes, nanoparticles and microcapsules.</p>

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Biomedical Applications and Properties of Sericin-Based Microcapsules in Drug Delivery and Tissue Engineering

  • 期刊论文

  • 发表日期：

    2025年8月4日

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  • Maryam Ilyas,
  • Aamir Ali,
  • Hafiz Muhammad Tahir,
  • Ayesha Muzamil,
  • Rimsha Yaqoob,
  • Zoya Abid

摘要

Abstract

Silk sericin, a natural biomaterial composed of 18 amino acids, possesses diverse biological properties such as water solubility, UV resistant activity, biocompatibility, non-cytotoxicity and moisturizing ability. Moreover, this protein has antioxidant, anti-inflammatory and regenerative potential. With the latest developments, the sericin-based microcapsules, hydrogels, nanoparticles, scaffolds and other biomaterials have been developed by combining sericin with different synthetic polymers. Sericin microcapsules (including microspheres and micro-particles) have complex features and are used in drug delivery, regenerative medicines, wound healing, nutraceuticals and many other applications. All these features of sericin make it a favorable polymer as it has potential in biomedicine as therapeutic as well as drug delivery agent. In this review, the important properties and biomedical applications of sericin microcapsules in biomedicine, tissue engineering, drug delivery, cosmetics and pharmacological industries are discussed.

Lay Summary

The biomedical research is now focused on unfolding the biological potential of natural protein polymers and the development of novel drug delivery agents. Sericin is a natural protein that has vast biologicals potentials including regenerative, antioxidant, anti-inflammatory and antidiabetic potentials as well as can be used in the production of novel drug delivery agents including scaffolds, hydrogels, microparticles, liposomes, nanoparticles and microcapsules.