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Purpose <p>Three-dimensional (3D) bioprinting has emerged as a transformative frontier in regenerative medicine, offering unprecedented opportunities for the fabrication of patient-specific constructs that closely recapitulate native tissue architecture. This review critically examines the evolution of 3D bioprinting technologies in wound healing applications, with a particular focus on bioink innovation and precision scaffold design for personalized therapeutic strategies.</p> Methods <p>A systematic synthesis of cutting-edge bioprinting modalities including inkjet bioprinting, fused deposition modeling, electrohydrodynamic bioprinting, and stereolithography was undertaken to elucidate their respective roles in generating structurally and functionally biomimetic scaffolds. Special emphasis was placed on the integration of natural and synthetic biomaterials (e.g., sericin, chitosan, polyethylene glycol, agarose, collagen, and gelatin) with bioactive agents to formulate advanced, cell-laden bioinks. The role of high-resolution anatomical imaging (X-ray, MRI, µCT) and computer-aided design (CAD) platforms in enabling spatially controlled, patient-specific scaffold fabrication was also examined.</p> Results <p>Contemporary 3D bioprinting techniques enable the fabrication of highly organized, biologically active scaffolds with uniform cellular distribution and tailored microarchitecture. The strategic incorporation of bioactive molecules with antimicrobial, antioxidant, and anti-inflammatory properties has been shown to significantly accelerate wound closure by enhancing cellular proliferation, extracellular matrix remodeling, and neovascularization—key hallmarks of tissue regeneration.</p> Conclusion <p>3D bioprinting is redefining the landscape of wound management by facilitating the development of customizable, bioactive constructs that address patient-specific pathophysiological needs. The convergence of advanced biomaterials, bioprinting precision, and biologically inspired design principles positions this technology as a cornerstone in next-generation regenerative therapeutics.</p> Lay summary <p>Wound healing is especially challenging in severe cases like burns or chronic ulcers. Traditional dressings such as gauze and bandages often fall short, leading to scarring and poor moisture retention. 3D bioprinting offers a groundbreaking alternative by using living cells and biomaterials to "print" skin-like structures tailored to each patient. These bioengineered constructs promote faster, more natural healing while reducing complications. This review explores how 3D bioprinting is transforming wound care through personalized therapies, innovative bioinks, and advanced printing techniques. It also highlights current challenges and future prospects, including the potential to print full-thickness skin grafts for clinical use.</p> Graphical Abstract <p></p>

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Biofabrication Unraveled: 3D Bioprinting as a Paradigm Shift in Wound Care

  • 期刊论文

  • 发表日期：

    2025年7月3日

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  • Shalini Singla,
  • Dimple Sethi Chopra,
  • Anjana Choudhary,
  • Maria Scimran Blossom Da Costa,
  • Abhishek Gupta,
  • Dhandeep Singh,
  • Nirmal Singh

摘要

Purpose

Three-dimensional (3D) bioprinting has emerged as a transformative frontier in regenerative medicine, offering unprecedented opportunities for the fabrication of patient-specific constructs that closely recapitulate native tissue architecture. This review critically examines the evolution of 3D bioprinting technologies in wound healing applications, with a particular focus on bioink innovation and precision scaffold design for personalized therapeutic strategies.

Methods

A systematic synthesis of cutting-edge bioprinting modalities including inkjet bioprinting, fused deposition modeling, electrohydrodynamic bioprinting, and stereolithography was undertaken to elucidate their respective roles in generating structurally and functionally biomimetic scaffolds. Special emphasis was placed on the integration of natural and synthetic biomaterials (e.g., sericin, chitosan, polyethylene glycol, agarose, collagen, and gelatin) with bioactive agents to formulate advanced, cell-laden bioinks. The role of high-resolution anatomical imaging (X-ray, MRI, µCT) and computer-aided design (CAD) platforms in enabling spatially controlled, patient-specific scaffold fabrication was also examined.

Results

Contemporary 3D bioprinting techniques enable the fabrication of highly organized, biologically active scaffolds with uniform cellular distribution and tailored microarchitecture. The strategic incorporation of bioactive molecules with antimicrobial, antioxidant, and anti-inflammatory properties has been shown to significantly accelerate wound closure by enhancing cellular proliferation, extracellular matrix remodeling, and neovascularization—key hallmarks of tissue regeneration.

Conclusion

3D bioprinting is redefining the landscape of wound management by facilitating the development of customizable, bioactive constructs that address patient-specific pathophysiological needs. The convergence of advanced biomaterials, bioprinting precision, and biologically inspired design principles positions this technology as a cornerstone in next-generation regenerative therapeutics.

Lay summary

Wound healing is especially challenging in severe cases like burns or chronic ulcers. Traditional dressings such as gauze and bandages often fall short, leading to scarring and poor moisture retention. 3D bioprinting offers a groundbreaking alternative by using living cells and biomaterials to "print" skin-like structures tailored to each patient. These bioengineered constructs promote faster, more natural healing while reducing complications. This review explores how 3D bioprinting is transforming wound care through personalized therapies, innovative bioinks, and advanced printing techniques. It also highlights current challenges and future prospects, including the potential to print full-thickness skin grafts for clinical use.

Graphical Abstract