Purpose <p>The primary technique used in current tissue regeneration techniques is tissue restoration through implantation of synthetic or natural materials. On the other hand, the need for tissue engineering techniques has grown due to the shortcomings of the current strategies. This work aims to document the most recent advancements in Biomaterial used in Regenerative Medicine through Tissue Engineering.</p> Methods <p>This study reviews the vast array of journals (2005–2025) to emphasize different biomaterials used for regenerative medicines.</p> Results <p>Tissue engineering is based on three core components: biodegradable scaffolds, seed cells, and nutritional factors. A key factor in the success of tissue engineering is the choice of suitable techniques for scaffold fabrication, tissue transplantation, and cell stimulation.</p> Conclusion <p>Despite the wide range of factors accessible, the practical efficacy is determined by their appropriate combination and synergistic effect. Therefore, an in-depth comprehensive view of tissue engineering and its various facts are examined in this review.</p> Lay Summary <p>The primary approach in current tissue regeneration methods involves tissue restoration through the implantation of synthetic or natural materials. However, the limitations of these existing strategies have increased the demand for tissue engineering techniques. Tissue engineering relies on three core principles: adequate cell supply, effective cell modification, and a suitable supporting matrix. The success of tissue engineering is largely dependent on selecting appropriate techniques for scaffold fabrication, tissue transplantation, and cell stimulation. While a wide range of factors are available, their practical effectiveness depends on how well they are combined and their synergistic effects. This review provides an in-depth information of tissue engineering and its various aspects.</p> Graphical Abstract <p></p>