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Background <p>The gut microbiota plays a vital role in maintaining human homeostasis, affecting immunity and contributing to the pathogenesis of various diseases. The dynamic interactions between the gut microbiota and the host immune system highlight the importance of gut-derived metabolites, particularly short-chain fatty acids (SCFAs), which influence immune responses and overall health.</p> Purpose <p>This article aims to explore the intricate relationship between gut microbiota, immune system regulation, and disease pathogenesis. It discusses the impact of dysbiosis on immune cells, the differences in microbiota composition based on gender, and the therapeutic interventions required to restore and maintain gut health.</p> Results <p>The article highlights the essential functions of gut microbiota–derived metabolites in promoting immune health, focusing on SCFAs and other key metabolites. It also describes the consequences of dysbiosis on the immune system, particularly on B- and T-cell function. A detailed explanation of the progressive stages of dysbiosis, including mucosal barrier breakdown, microbial translocation, and inflammasome activation, is provided. The importance of gender differences in microbiota composition and the role of microbiota in maintaining immune homeostasis are emphasized.</p> Conclusion <p>Maintaining a balanced gut microbiome (eubiosis) is crucial for preventing diseases and promoting overall health. Dysbiosis, or the imbalance in gut microbiota, can lead to significant health problems, including chronic inflammation and compromised immunity. The article underscores the importance of dietary and therapeutic interventions to restore and maintain eubiosis, with strategies aimed at preventing dysbiosis.</p> Lay Summary <p>This article explains how the bacteria in our gut are vital for keeping us healthy by supporting our immune system and preventing diseases. It discusses how an imbalance in gut bacteria, called dysbiosis, can lead to various health problems. The article also talks about the importance of maintaining a healthy gut through diet and other therapies to ensure overall well-being.</p> Graphical Abstract <p></p>

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From Gut to Glory: Unveiling the Microbiome’s Impact on Human Health

  • 期刊论文

  • 发表日期：

    2025年4月11日

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  • Yogesh Raval,
  • Mohammadakil Shaikh,
  • Kiran Dudhat

摘要

Background

The gut microbiota plays a vital role in maintaining human homeostasis, affecting immunity and contributing to the pathogenesis of various diseases. The dynamic interactions between the gut microbiota and the host immune system highlight the importance of gut-derived metabolites, particularly short-chain fatty acids (SCFAs), which influence immune responses and overall health.

Purpose

This article aims to explore the intricate relationship between gut microbiota, immune system regulation, and disease pathogenesis. It discusses the impact of dysbiosis on immune cells, the differences in microbiota composition based on gender, and the therapeutic interventions required to restore and maintain gut health.

Results

The article highlights the essential functions of gut microbiota–derived metabolites in promoting immune health, focusing on SCFAs and other key metabolites. It also describes the consequences of dysbiosis on the immune system, particularly on B- and T-cell function. A detailed explanation of the progressive stages of dysbiosis, including mucosal barrier breakdown, microbial translocation, and inflammasome activation, is provided. The importance of gender differences in microbiota composition and the role of microbiota in maintaining immune homeostasis are emphasized.

Conclusion

Maintaining a balanced gut microbiome (eubiosis) is crucial for preventing diseases and promoting overall health. Dysbiosis, or the imbalance in gut microbiota, can lead to significant health problems, including chronic inflammation and compromised immunity. The article underscores the importance of dietary and therapeutic interventions to restore and maintain eubiosis, with strategies aimed at preventing dysbiosis.

Lay Summary

This article explains how the bacteria in our gut are vital for keeping us healthy by supporting our immune system and preventing diseases. It discusses how an imbalance in gut bacteria, called dysbiosis, can lead to various health problems. The article also talks about the importance of maintaining a healthy gut through diet and other therapies to ensure overall well-being.

Graphical Abstract