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Abstract <p>Chronic wound healing is a disorder that can lead to many socioeconomic factors, including social and familial isolation, and psychological effects such as loss of self-regard and depression. Wound healing poses a monumental setback to the healthcare systems necessitating innovative approaches to address this challenge. Lately, a considerable amount of interest has been shown in novel therapies by targeting individual biomolecules and investigating the modulation of reactive oxygen and nitrogen species (RONS) involved in wound healing. Cold atmospheric plasma (CAP) technology is a novel technique that holds the ability to tune the generated reactive species according to the specific wound type, thus terminating the etiology-dependent conventional wound care methods. The US FDA has given clearance to study CAP-based devices for cancer applications. However, only the CE has approved it for wound healing applications, suggesting a pressing requirement for extensive research efforts in this domain, potentially paving the way for the practical utilization of CAP-based medical devices. Wound healing encompasses the expression and alteration of a multitude of proteins. This review underscores the importance of comprehending how CAP interacts with these proteins, which is pivotal for effectively employing CAP as a medical device.</p> Lay Summary <p> Cold atmospheric plasma (CAP) has revolutionized wound healing over the past few decades, delivering remarkable results. Yet, a crucial gap remains in our understanding of the diverse proteins that drive this healing process. This review aims to bridge that gap, shedding light on the unexplored protein interactions and how a deeper dive into their roles can elevate the effectiveness of CAP technology.</p> Graphical Abstract <p>The review underscores cold atmospheric plasma (CAP) technology as a promising method for wound healing, stressing the significance of comprehending its interaction with proteins to ensure optimal utilization of medical devices.</p> <p></p>

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Cold Atmospheric Plasma as a Promising Medical Device for Wound Healing: Implications from Protein Perspective

  • 期刊论文

  • 发表日期：

    2025年4月11日

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  • Priya Bhatt,
  • Reema,
  • Kamatchi Sankaranarayanan

摘要

Abstract

Chronic wound healing is a disorder that can lead to many socioeconomic factors, including social and familial isolation, and psychological effects such as loss of self-regard and depression. Wound healing poses a monumental setback to the healthcare systems necessitating innovative approaches to address this challenge. Lately, a considerable amount of interest has been shown in novel therapies by targeting individual biomolecules and investigating the modulation of reactive oxygen and nitrogen species (RONS) involved in wound healing. Cold atmospheric plasma (CAP) technology is a novel technique that holds the ability to tune the generated reactive species according to the specific wound type, thus terminating the etiology-dependent conventional wound care methods. The US FDA has given clearance to study CAP-based devices for cancer applications. However, only the CE has approved it for wound healing applications, suggesting a pressing requirement for extensive research efforts in this domain, potentially paving the way for the practical utilization of CAP-based medical devices. Wound healing encompasses the expression and alteration of a multitude of proteins. This review underscores the importance of comprehending how CAP interacts with these proteins, which is pivotal for effectively employing CAP as a medical device.

Lay Summary

Cold atmospheric plasma (CAP) has revolutionized wound healing over the past few decades, delivering remarkable results. Yet, a crucial gap remains in our understanding of the diverse proteins that drive this healing process. This review aims to bridge that gap, shedding light on the unexplored protein interactions and how a deeper dive into their roles can elevate the effectiveness of CAP technology.

Graphical Abstract

The review underscores cold atmospheric plasma (CAP) technology as a promising method for wound healing, stressing the significance of comprehending its interaction with proteins to ensure optimal utilization of medical devices.