Abstract <p>Neurocosmetics is an emerging field of cosmetic research that combines dermatology and neuroscience to address various skin conditions by leveraging the brain-skin connection. This review explores several scientific aspects of neurocosmetics, including how the roles of neurotransmitter modulation, neuropeptides, and sensory pathways in influencing skin health and aging. A review of the safety considerations and legal frameworks was also conducted, in addition to stem cell research’s particular synergistic function in skin regeneration.</p> Lay Summary <p>The skin serves as a protective barrier against external invasion and an important body part in regulating bodily functions and well-being. Neurocosmetics is a new field in the research of the interaction between the brain and skin for advanced skincare, modulating neurotransmitters to draw deeper benefits not achievable by traditional treatments. This review addresses neurocosmetics and its potential to revolutionize skincare, ranging from anti-aging and rejuvenation to stem cell research, focusing on safety and regulations.</p>