Abstract <p>Enormous advancements have been achieved in the biosciences ever since the discovery of stem cell technology. These advancements have paved the way for new research to be conducted on the unsolved problems that still exist in stem cell technology, tissue engineering, and regenerative medicine. The process of changing adult stem cells into pluripotent stem cells, which is sometimes referred to as nuclear programming, has been a popular subject of research in the field of biosciences, despite the presence of ongoing moral and logistical challenges. Stem cell therapy has been proven to be incredibly advantageous for stem cell transplantation owing to its promised advantages over the limits of autologous transplantation of a person’s tissues, even though stem cell-based treatment is not entirely capable of curing illnesses. The shortcomings of stem cell treatment have inspired researchers to conceive of potential solutions including tissue engineering technologies for regenerative medicine because stem cell transplantation seems extremely beneficial and promising. The field of regenerative medicine has been included in the field as a result of the development of embryonic stem cell technology, which has led to a resurgence of attempts to combine potentially fruitful tissue engineering techniques. In this review, we have discussed the potential of pluripotency of embryonic stem cells in the disease model, their relation in functional tissue engineering, regenerative medicine therapies at the clinical stage and pre-clinical phase and try to explore the breakthroughs that have already taken place, and future connections between stem cell technology and tissue engineering to potentiate regenerative medicine and futuristic effective therapeutics.</p> Lay Summary <p>The treatment of disease using primary patient-derived cells is useful for the study of the human condition, etiology, and the development of new avenues of stem cell–based tissue engineering and regenerative medicine in the field of human disease therapeutics. The lack of expandable primary cell culture, however, is a crucial limitation, especially in cells that are hard to reach, such as the brain and heart cell systems. Human-induced pluripotent stem cells (iPSC) may also be an enticing option, as theoretical use of iPSCs that are readily obtained from accessible cell types, such as skin fibroblasts, and blood cells, can be used in human illness (especially those with known genetic causes). Due to their internal nature, self-renovation, and differentiation capacities, iPSCs can provide vast numbers of disease-relevant cells that could potentiate regenerative medicine and future therapeutics.</p>

Correlation in Stem Cell Technology, Tissue Engineering, and Regenerative Medicine

期刊论文
发表日期：

2025年2月3日

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Sharda Bharti,
Awanish Kumar

摘要

Abstract

Enormous advancements have been achieved in the biosciences ever since the discovery of stem cell technology. These advancements have paved the way for new research to be conducted on the unsolved problems that still exist in stem cell technology, tissue engineering, and regenerative medicine. The process of changing adult stem cells into pluripotent stem cells, which is sometimes referred to as nuclear programming, has been a popular subject of research in the field of biosciences, despite the presence of ongoing moral and logistical challenges. Stem cell therapy has been proven to be incredibly advantageous for stem cell transplantation owing to its promised advantages over the limits of autologous transplantation of a person’s tissues, even though stem cell-based treatment is not entirely capable of curing illnesses. The shortcomings of stem cell treatment have inspired researchers to conceive of potential solutions including tissue engineering technologies for regenerative medicine because stem cell transplantation seems extremely beneficial and promising. The field of regenerative medicine has been included in the field as a result of the development of embryonic stem cell technology, which has led to a resurgence of attempts to combine potentially fruitful tissue engineering techniques. In this review, we have discussed the potential of pluripotency of embryonic stem cells in the disease model, their relation in functional tissue engineering, regenerative medicine therapies at the clinical stage and pre-clinical phase and try to explore the breakthroughs that have already taken place, and future connections between stem cell technology and tissue engineering to potentiate regenerative medicine and futuristic effective therapeutics.

Lay Summary

The treatment of disease using primary patient-derived cells is useful for the study of the human condition, etiology, and the development of new avenues of stem cell–based tissue engineering and regenerative medicine in the field of human disease therapeutics. The lack of expandable primary cell culture, however, is a crucial limitation, especially in cells that are hard to reach, such as the brain and heart cell systems. Human-induced pluripotent stem cells (iPSC) may also be an enticing option, as theoretical use of iPSCs that are readily obtained from accessible cell types, such as skin fibroblasts, and blood cells, can be used in human illness (especially those with known genetic causes). Due to their internal nature, self-renovation, and differentiation capacities, iPSCs can provide vast numbers of disease-relevant cells that could potentiate regenerative medicine and future therapeutics.