<p>Wound management and acceleration of the healing process is influenced by a complex and coordinated set of cells and molecules. Disturbance in this process leads to longer treatment time, scar formation, and chronic wound which causes several complications. Therefore, it is necessary to understand and apply the appropriate treatment to different types of wounds. Exosomes can be mentioned as an effective novel cell-free strategy for the treatment of wounds. Exosomes as a population of extracellular vesicles have the characteristics of their parental cells and carry various components including functional protein and RNA factors. Exosomal factors specially depend on the type of cell that produced them. In this regard, stem cells, especially mesenchymal stem cell-derived exosomes have shown potentials in regenerative medicine and wound healing. Although MSC-derived exosomes are efficient in treatment of wounds that is comparable to other traditional treatment methods, they also have some innate limitations. Currently, scientists have the tendency to develop designed or engineered exosomes for overcoming some of the limitations. In this review, we explained the process of wound healing and exosomes from a molecular and cellular point of view. In addition, we reviewed the latest research of the application of natural and engineered exosomes in the wound healing process.</p> Graphical Abstract <p></p>