Preparation of Bioscaffold Supported by Chitosan and Nanocurcumin to Promote Tissue Engineering

In this work, a combination of chitosan (C) and nanocurcumin (N-CU) was used to fabricate a chitosan-nanocurcumin scaffold (CnCS), by sheet-casting method, for their potential application in tissue engineering application.

The developed CnCS were studied using physicochemical, mechanical, biocompatible, and antibacterial properties.

The prepared CnCS exhibited good mechanical properties. On CnCS, the biocompatibility properties of the human keratinocyte cell line (HaCaT) were demonstrated, and its biocompatible nature. CnCS antimicrobial properties were proven in our study. No statistically significant differences were identified between chitosan scaffold (CF) (CF-prepared without N-CU) and CnCS in mechanical and antimicrobial properties. Significant differences were observed in cell viability between the CnCS (p < 0.05).

The study developed a method for producing an active bioscaffold, which contains skin tissue engineering substitute material, using synthetic alternatives. These results suggested that the CnCS bioscaffold could be a promising material for wound healing applications.

A wound is an injury that results in damage to human organs or tissues caused by an internal or external fracture. Wound dressing materials made from natural substances are effective in healing both chronic and acute wounds. Wound dressing material formulations are preferable because of the good properties delivered by natural materials. The developed bioscaffold provide a unique method using natural resource and promote tissue engineering.