We study the integrability of coupled Painlevé systems with affine Weyl group symmetry of type \(A^{(2)}_4\) , which in short we call the Sasano system of type \(A^{(2)}_4\) , from the point of view of the Hamiltonian dynamics. We prove rigorously that for all values of the parameters for which the Sasano system of type \(A^{(2)}_4\) has a particular rational solution it is not integrable by rational first integrals. By an explicit computation we show that the connected component \(G^0\) of the unit element of the differential Galois group of the normal variational equations along a simple particular rational solution is a direct product of two groups \(\textrm{SL}_2({{\mathbb {C}}})\) . Applying the Morales–Ramis theory we provide a nonintegrable system. Moreover, using Bäcklund transformations we extend the obtained particular result to an orbit of the parameters.