Scholarlink

Purpose <p>This study was to investigate the feasibility of a new collimation technology for cardiac single photon emission computerized tomography (SPECT) to differentiate the sub-epicardial and sub-endocardial regions in the myocardium using a cardiac phantom configured with normal, non-transmural and transmural myocardial perfusion defects.</p> Methods <p>The cardiac phantom was filled with <sup>99m</sup>Tc solution and was scanned using a dual-head NaI-based SPECT camera, one head mounted with a new spread field imaging (SFI) collimator and the other with a conventional parallel-hole collimator. Images were acquired in list mode format and were reconstructed using iterative ordered subset expectation maximization (OSEM) algorithms. Mean SPECT intensities derived from the normal, non-transmural and transmural regions simulated in the cardiac phantom were calculated for quantitative comparisons between SFI and conventional SPECT.</p> Results <p>SPECT spatial resolution was much improved using the new SFI collimator. The sub-endocardium and sub-epicardium simulated in the cardiac phantom could be clearly separated and visualized, and the simulated transmural and non-transmural defects were better discernable and quantifiable with SFI SPECT as compared to parallel-hole collimated SPECT.</p> Conclusion <p>The SFI collimation and reconstruction techniques may have a great potential of differentiating the sub-endocardial and sub-epicardial regions in cardiac SPECT, improving the quantitative assessment of non-transmural perfusion gradients in patients with known or suspected coronary artery disease.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Potential of Spread Field Imaging Collimation Technology in SPECT to Differentiate Sub-endocardial and Sub-epicardial Regions: A Phantom Study

  • 期刊论文

  • 发表日期：

    2026年2月9日

查看全文
  • Yi-Hwa Liu,
  • Richard Palyo,
  • Divyani Goyal,
  • Chi Liu,
  • Zhiqiang Mu,
  • Zhong Tao,
  • Albert J. Sinusas,
  • Edward J. Miller,
  • Zhiping Mu

摘要

Purpose

This study was to investigate the feasibility of a new collimation technology for cardiac single photon emission computerized tomography (SPECT) to differentiate the sub-epicardial and sub-endocardial regions in the myocardium using a cardiac phantom configured with normal, non-transmural and transmural myocardial perfusion defects.

Methods

The cardiac phantom was filled with 99mTc solution and was scanned using a dual-head NaI-based SPECT camera, one head mounted with a new spread field imaging (SFI) collimator and the other with a conventional parallel-hole collimator. Images were acquired in list mode format and were reconstructed using iterative ordered subset expectation maximization (OSEM) algorithms. Mean SPECT intensities derived from the normal, non-transmural and transmural regions simulated in the cardiac phantom were calculated for quantitative comparisons between SFI and conventional SPECT.

Results

SPECT spatial resolution was much improved using the new SFI collimator. The sub-endocardium and sub-epicardium simulated in the cardiac phantom could be clearly separated and visualized, and the simulated transmural and non-transmural defects were better discernable and quantifiable with SFI SPECT as compared to parallel-hole collimated SPECT.

Conclusion

The SFI collimation and reconstruction techniques may have a great potential of differentiating the sub-endocardial and sub-epicardial regions in cardiac SPECT, improving the quantitative assessment of non-transmural perfusion gradients in patients with known or suspected coronary artery disease.