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Purpose <p>The aim of this study was to compare the radial deformation properties (stiffness index and M-mode strain) of different segments of native femoropopliteal arteries and arteries after various reconstructive interventions under physiological conditions using ultrasound imaging.</p> Methods <p>A prospective cohort study was conducted (<i>n</i> = 70). Three study groups were formed: Group 1 (<i>n</i> = 10) – healthy volunteers; Group 2 – patients after intraluminal recanalization of the superficial femoral artery (SFA) [remote endarterectomy (<i>n</i> = 10), endovascular recanalization with laser-cut (<i>n</i> = 10) or interwoven nitinol stent (<i>n</i> = 10)]; Group 3 – patients after femoropopliteal bypass [with autologous vein (<i>n</i> = 10), xenogeneic graft (<i>n</i> = 10), or synthetic ePTFE graft (<i>n</i> = 10)]. All participants underwent ultrasound measurement of stiffness index and M-mode strain (Mmst) at 5 points.</p> Results <p>The Mmst of femoropopliteal artery walls in the supine position averaged 10%, except in Hunter’s canal, where it was almost four times lower (2.8%, <i>p</i> &lt; 0.001). In the supine position, the desobliterated SFA in Hunter’s canal had an Mmst twice as high (5.6%) as that of the native artery. The stented SFA demonstrated a significant decrease in Mmst in both positions (0.6–0.7%). Autovenous grafts showed higher Mmst in the Hunter’s canal projection (9.0% and 6% in the supine and standing positions, respectively). The synthetic graft showed almost no wall Mmst during pulsation (0.1%) in either position.</p> Conclusion <p>The unsuitable biomechanical properties of stents and synthetic grafts explain the unsatisfactory outcomes of revascularizations. Further development of artificial materials and devices with biomechanical properties similar to native arteries is necessary.</p>

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Evaluation of the Biomechanical Properties of Femoropopliteal Arteries Under Physiological Conditions in Healthy Volunteers and Patients After Infrainguinal Revascularisation

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • Alexander Gostev,
  • Olesia Osipova,
  • Irina Volkova,
  • Vladimir Starodubtsev,
  • Dmitry Lysikov,
  • Shoraan Saaya,
  • Pavel Ignatenko,
  • Oleg Krestyaninov,
  • Andrey Karpenko,
  • Alexander Chernyavsky

摘要

Purpose

The aim of this study was to compare the radial deformation properties (stiffness index and M-mode strain) of different segments of native femoropopliteal arteries and arteries after various reconstructive interventions under physiological conditions using ultrasound imaging.

Methods

A prospective cohort study was conducted (n = 70). Three study groups were formed: Group 1 (n = 10) – healthy volunteers; Group 2 – patients after intraluminal recanalization of the superficial femoral artery (SFA) [remote endarterectomy (n = 10), endovascular recanalization with laser-cut (n = 10) or interwoven nitinol stent (n = 10)]; Group 3 – patients after femoropopliteal bypass [with autologous vein (n = 10), xenogeneic graft (n = 10), or synthetic ePTFE graft (n = 10)]. All participants underwent ultrasound measurement of stiffness index and M-mode strain (Mmst) at 5 points.

Results

The Mmst of femoropopliteal artery walls in the supine position averaged 10%, except in Hunter’s canal, where it was almost four times lower (2.8%, p < 0.001). In the supine position, the desobliterated SFA in Hunter’s canal had an Mmst twice as high (5.6%) as that of the native artery. The stented SFA demonstrated a significant decrease in Mmst in both positions (0.6–0.7%). Autovenous grafts showed higher Mmst in the Hunter’s canal projection (9.0% and 6% in the supine and standing positions, respectively). The synthetic graft showed almost no wall Mmst during pulsation (0.1%) in either position.

Conclusion

The unsuitable biomechanical properties of stents and synthetic grafts explain the unsatisfactory outcomes of revascularizations. Further development of artificial materials and devices with biomechanical properties similar to native arteries is necessary.