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<p>Biological ion channels can respond to environmental stimuli, exhibiting multistate transport behavior that transcends simple binary “open-closed” conformations. This provides a dynamically controllable molecular basis for neural signal processing and substance transport across cell membranes. Inspired by this, this study synthesized a triphenylamine-ketone D-A (Donor-Acceptor) type poly(aryl amine-ketone) through molecular design. This polymer possesses multiple redox sites, enabling continuously tunable electrochemical states through hierarchical electron transfer. By combining it with two-dimensional conductive MXene, a biomimetic nanofluidic transistor was constructed. Through side-group tuning to optimize redox matching, the polymer undergoes reversible conformation switching through intramolecular charge transfer at voltages below 1 V. The field-driven conformation changes induce electrostatic attraction that promotes reversible contraction of the MXene interlayers. Ultimately, through the synergistic coupling of MXene interlayer spacing variation and dynamic rearrangement of interfacial charges, the device achieves precise hierarchical control over ion flux. It successfully simulates three switchable ion transport states—“closed”, “partially open”, and “fully open”—with an ion switching ratio of 10 and demonstrates outstanding cycling stability. Furthermore, synaptic plasticity featured by the device emulates fundamental attributes of biological signaling, delivering a foundation for the development of bioinspired neuromorphic devices.</p>

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Bioinspired voltage-gated multi-state ion channels in MXene nanoconfinement for emulating synaptic plasticity

  • 期刊论文

  • 发表日期：

    2026年4月29日

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  • Tingting Xu,
  • Hongyan Qi,
  • Jundong Zhong,
  • Shuang Zhao,
  • Weibo Sun,
  • Shiyi Li,
  • Zhenhua Jiang,
  • Xuanbo Zhu

摘要

Biological ion channels can respond to environmental stimuli, exhibiting multistate transport behavior that transcends simple binary “open-closed” conformations. This provides a dynamically controllable molecular basis for neural signal processing and substance transport across cell membranes. Inspired by this, this study synthesized a triphenylamine-ketone D-A (Donor-Acceptor) type poly(aryl amine-ketone) through molecular design. This polymer possesses multiple redox sites, enabling continuously tunable electrochemical states through hierarchical electron transfer. By combining it with two-dimensional conductive MXene, a biomimetic nanofluidic transistor was constructed. Through side-group tuning to optimize redox matching, the polymer undergoes reversible conformation switching through intramolecular charge transfer at voltages below 1 V. The field-driven conformation changes induce electrostatic attraction that promotes reversible contraction of the MXene interlayers. Ultimately, through the synergistic coupling of MXene interlayer spacing variation and dynamic rearrangement of interfacial charges, the device achieves precise hierarchical control over ion flux. It successfully simulates three switchable ion transport states—“closed”, “partially open”, and “fully open”—with an ion switching ratio of 10 and demonstrates outstanding cycling stability. Furthermore, synaptic plasticity featured by the device emulates fundamental attributes of biological signaling, delivering a foundation for the development of bioinspired neuromorphic devices.