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<p>Chirality plays a fundamental role in molecular recognition and biological function, yet its integration into inorganic clusters remains a considerable challenge. Polyoxometalates (POMs), characterized by atomic precision, structural tunability, and versatile redox properties, represent an exceptional platform for investigating chirality at the intersection of inorganic chemistry and biomedicine. Over the past two decades, substantial progress has been achieved in constructing chiral POM-based materials through diverse strategies, including chirality induction by external environments, intrinsic structural chirality, and spontaneous symmetry breaking, as well as the design of self-assembled supramolecular architectures. The distinctive combination of redox activity, stability, and chirality in these systems has unlocked new avenues for biomedical applications, spanning antibacterial and anticancer therapies to potential interventions in neurodegenerative disorders. This review provides a comprehensive overview of recent advances in the synthesis and biomedical applications of chiral POM-based materials, while we also outline the key challenges and opportunities that will guide future research in this emerging field.</p>

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From structural chirality to coined biomedical function: recent advances in chiral polyoxometalate-based materials

  • 期刊论文

  • 发表日期：

    2026年3月11日

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  • Zhibo Tong,
  • Junlin Ya,
  • Yue Sun,
  • Jinsong Ren,
  • Xiaogang Qu

摘要

Chirality plays a fundamental role in molecular recognition and biological function, yet its integration into inorganic clusters remains a considerable challenge. Polyoxometalates (POMs), characterized by atomic precision, structural tunability, and versatile redox properties, represent an exceptional platform for investigating chirality at the intersection of inorganic chemistry and biomedicine. Over the past two decades, substantial progress has been achieved in constructing chiral POM-based materials through diverse strategies, including chirality induction by external environments, intrinsic structural chirality, and spontaneous symmetry breaking, as well as the design of self-assembled supramolecular architectures. The distinctive combination of redox activity, stability, and chirality in these systems has unlocked new avenues for biomedical applications, spanning antibacterial and anticancer therapies to potential interventions in neurodegenerative disorders. This review provides a comprehensive overview of recent advances in the synthesis and biomedical applications of chiral POM-based materials, while we also outline the key challenges and opportunities that will guide future research in this emerging field.