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<p>The escalating global challenge of antibiotic contamination demands advanced sensing technologies for environmental monitoring and public health protection. Herein, we present a structurally well-defined, intercalation-engineered MOF (HSB-W18) that functions as an ultrasensitive and selective fluorescence sensor for fluoroquinolone antibiotics. Comprehensive single-crystal X-ray diffraction analysis unambiguously determines both the framework architecture and the spatial organization of intercalated 2,5-dihydroxyterephthalate molecules at atomic resolution. Through ultrasound-assisted synthesis, highly stable book-shaped microsheets (HSB-W18-MS) that maintain exceptional aqueous dispersibility and luminescence intensity for extended periods (&gt;1 month) are obtained, which offer distinct advantages for antibiotic detection: specific recognition of diverse fluoroquinolones via unique fluorescence signatures; highly sensitive ratiometric detection of enoxacin (ENX) (LOD = 5.62 nM) and rapid response kinetics (&lt;30 s); exceptional selectivity alongside reusability. Systematic mechanistic investigations reveal a synergistic detection process involving multiple photophysical pathways. Furthermore, we successfully implemented a smartphone-based portable detection system and validated the practical utility of this sensor through its selectivity and reusability, as demonstrated by its ability to quantify ENX in complex environmental samples (tap water: LOD = 18.32 nM; river water: LOD = 29.87 nM). This study makes significant contributions to both fundamental materials science and environmental monitoring. Specifically, it elucidates discernible structure-property relationships in intercalated MOFs, demonstrating a robust platform for field-deployable antibiotic detection and proposing an innovative design paradigm for environmental optical sensors.</p>

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Intercalation-engineered MOF for ultrasensitive ratiometric fluorescent sensing of enoxacin

  • 期刊论文

  • 发表日期：

    2026年2月25日

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  • Liping Wang,
  • Jinling Huang,
  • Haitao Li,
  • Qi-Long Zhu,
  • Tian-Lu Sheng,
  • Xin-Tao Wu,
  • Yuehong Wen

摘要

The escalating global challenge of antibiotic contamination demands advanced sensing technologies for environmental monitoring and public health protection. Herein, we present a structurally well-defined, intercalation-engineered MOF (HSB-W18) that functions as an ultrasensitive and selective fluorescence sensor for fluoroquinolone antibiotics. Comprehensive single-crystal X-ray diffraction analysis unambiguously determines both the framework architecture and the spatial organization of intercalated 2,5-dihydroxyterephthalate molecules at atomic resolution. Through ultrasound-assisted synthesis, highly stable book-shaped microsheets (HSB-W18-MS) that maintain exceptional aqueous dispersibility and luminescence intensity for extended periods (>1 month) are obtained, which offer distinct advantages for antibiotic detection: specific recognition of diverse fluoroquinolones via unique fluorescence signatures; highly sensitive ratiometric detection of enoxacin (ENX) (LOD = 5.62 nM) and rapid response kinetics (<30 s); exceptional selectivity alongside reusability. Systematic mechanistic investigations reveal a synergistic detection process involving multiple photophysical pathways. Furthermore, we successfully implemented a smartphone-based portable detection system and validated the practical utility of this sensor through its selectivity and reusability, as demonstrated by its ability to quantify ENX in complex environmental samples (tap water: LOD = 18.32 nM; river water: LOD = 29.87 nM). This study makes significant contributions to both fundamental materials science and environmental monitoring. Specifically, it elucidates discernible structure-property relationships in intercalated MOFs, demonstrating a robust platform for field-deployable antibiotic detection and proposing an innovative design paradigm for environmental optical sensors.