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<p>The administration of enemas has emerged as a promising therapeutic approach for the treatment of ulcerative colitis. However, clinical enema solutions fail to achieve high fluidity, inflammation modulation, and targeted adhesion simultaneously, all of which are crucial for the precise regulation of the reactive oxygen species (ROS)-rich colonic microenvironment. Herein, we have successfully developed a novel type of highly fluid probiotic contained enema solution (denoted as s-BSA-Fe+EcN) by facile integration of bovine serum albumin (BSA), Fe<sup>2+</sup>, and probiotic <i>Escherichia coli</i> Nissle 1917 (EcN). The high fluidity of s-BSA-Fe+EcN facilitates comprehensive coverage of irregular colorectal mucosa, and Fe<sup>2+</sup> in s-BSA-Fe+EcN enables H<sub>2</sub>O<sub>2</sub> scavenging and hydroxyl radicals generation, resulting in conformal coating of hydrogel (denoted as h-BSA-Fe+EcN) on ROS-rich lesions by the crosslinking of BSA. The targeted adhesion of h-BSA-Fe +EcN can effectively mitigate oxidative damage to both host tissues and probiotic viability. The feasibility of inflammation-targeted gelation has been demonstrated in a porcine model through endoscopic technology <i>in vivo</i>. As a result, h-BSA-Fe +EcN shows excellent therapeutic efficacy in a dextran sulfate sodium-induced mouse colitis model, offering an advanced strategy for the transanal treatment of colitis.</p>

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Lesion-targeted probiotic delivery via ROS-activated gelation and mucoadhesion for transanal treatment of colitis

  • 期刊论文

  • 发表日期：

    2026年3月17日

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  • Hui Zhou,
  • Guangyuan Chen,
  • Weiwen Liang,
  • Zixin Chen,
  • Xinglong Wang,
  • Weijie Liu,
  • Bingna Zheng,
  • Dingcai Wu,
  • Rongkang Huang

摘要

The administration of enemas has emerged as a promising therapeutic approach for the treatment of ulcerative colitis. However, clinical enema solutions fail to achieve high fluidity, inflammation modulation, and targeted adhesion simultaneously, all of which are crucial for the precise regulation of the reactive oxygen species (ROS)-rich colonic microenvironment. Herein, we have successfully developed a novel type of highly fluid probiotic contained enema solution (denoted as s-BSA-Fe+EcN) by facile integration of bovine serum albumin (BSA), Fe2+, and probiotic Escherichia coli Nissle 1917 (EcN). The high fluidity of s-BSA-Fe+EcN facilitates comprehensive coverage of irregular colorectal mucosa, and Fe2+ in s-BSA-Fe+EcN enables H2O2 scavenging and hydroxyl radicals generation, resulting in conformal coating of hydrogel (denoted as h-BSA-Fe+EcN) on ROS-rich lesions by the crosslinking of BSA. The targeted adhesion of h-BSA-Fe +EcN can effectively mitigate oxidative damage to both host tissues and probiotic viability. The feasibility of inflammation-targeted gelation has been demonstrated in a porcine model through endoscopic technology in vivo. As a result, h-BSA-Fe +EcN shows excellent therapeutic efficacy in a dextran sulfate sodium-induced mouse colitis model, offering an advanced strategy for the transanal treatment of colitis.