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<p>Circumventing the tumor’s defensive antioxidant system and achieving precision cancer therapy are the major challenges in achieving high-efficacy tumor treatments. In this study, we propose a rational and effective therapeutic strategy by synergistically integrating the effects of a non-oxidative physical ablation and an oxidative chemical intervention. An acid-responsive self-collapsing nanomineral PCSB is constructed, which consists of a poly(acrylic acid) (PAA)-modified calcium sulfite (CaSO<sub>3</sub>) and a pH-responsive photoacoustic (PA) therapeutic molecule, aza-BDP. The tumor acidic microenvironment promotes the decomposition of PCSB, triggering the release of PA agents and SO<sub>2</sub>/Ca<sup>2+</sup>, thereby achieving the synergistic therapy of non-oxidative mechanical damage from PA therapeutic effect and oxidative chemical damage from SO<sub>2</sub> gas and Ca<sup>2+</sup> metal ion therapeutic effects. Therefore, this study presents a synergistic physical and chemical treatment strategy, which shows significant potential for reducing the resistance conferred by the antioxidant mechanisms of tumor cells and improving the precision of treatment.</p>

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Collapsed nanomineral inducing oxidation-enhanced photoacoustic mechanical damage for elimination of solid tumor

  • 期刊论文

  • 发表日期：

    2026年1月6日

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  • Jiajun Li,
  • Ye Li,
  • Kemeng Zhang,
  • Wen Zhang,
  • Danhong Chen,
  • Xueyang Fang,
  • Tao Zhang

摘要

Circumventing the tumor’s defensive antioxidant system and achieving precision cancer therapy are the major challenges in achieving high-efficacy tumor treatments. In this study, we propose a rational and effective therapeutic strategy by synergistically integrating the effects of a non-oxidative physical ablation and an oxidative chemical intervention. An acid-responsive self-collapsing nanomineral PCSB is constructed, which consists of a poly(acrylic acid) (PAA)-modified calcium sulfite (CaSO3) and a pH-responsive photoacoustic (PA) therapeutic molecule, aza-BDP. The tumor acidic microenvironment promotes the decomposition of PCSB, triggering the release of PA agents and SO2/Ca2+, thereby achieving the synergistic therapy of non-oxidative mechanical damage from PA therapeutic effect and oxidative chemical damage from SO2 gas and Ca2+ metal ion therapeutic effects. Therefore, this study presents a synergistic physical and chemical treatment strategy, which shows significant potential for reducing the resistance conferred by the antioxidant mechanisms of tumor cells and improving the precision of treatment.