<p>Immunotherapy acts as an essential modality in modulating a broad variety of immune responses to cure diseases and has been regarded as a powerful therapeutic strategy in cancer treatment in the past decades. However, the application of immunotherapeutic agents is limited by their low tumor targeting capability, poor tumor penetration ability, and potential immune-related adverse events in physiological environments. Engineered liposomal nanoplatforms can help to reduce immune-related side effects, precisely deliver the drugs to the tumor site, and enhance the treatment power of immunotherapeutic agents by restricting them within the cavities of the liposomes and modifying the liposomes with targeting components and biocompatible materials to reduce their burst release, unwanted dispersion, and blood clearance. This review discusses the recent progress in the development of liposome-assisted immunotherapy for treating various cancers, including the design of liposomal nanoplatforms, the features of different immunotherapy modalities, and the strategies for activating immune responses. In addition, this review also introduces the strategies for strengthening liposome-based immunotherapy by optimizing liposomal design, exploring the pairing of different drugs, and combining with different therapeutic modalities. Finally, this review proposes some current limitations and future research directions for liposomal nanoplatform-assisted cancer immunotherapy.</p>