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<p>Bacterial infections seriously jeopardize human life and health. Photodynamic therapy (PDT), as an emerging noninvasive antibacterial strategy, has proven to be an effective treatment method against bacterial resistance. However, current photosensitizers suffer from inadequate free radical generation and limited functionality. To address this issue, a new <i>π</i>-conjugated viologen derivative, 3TPhDPyMeOTf, was designed. This derivative with multiple thiophene units enhances visible light absorption, and the presence of multiple pyridine structures allows the photosensitizer to generate more free radicals. Experimental and theoretical studies have demonstrated its inhibitory effect on bacterial growth both <i>in vitro</i> and <i>in vivo</i>, demonstrating a broad-spectrum antibacterial effect. The photosensitizer also exhibits excellent bacterial membrane staining, making it suitable for bacterial imaging. The design of this photosensitizer provides a new direction for the development of potent photosensitizers and photodynamic therapy.</p>

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Enhancing the ROS generation via polypyridine for bacteria imaging and photodynamic therapy

  • 期刊论文

  • 发表日期：

    2025年10月9日

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  • Mengying Guo,
  • Yujing Gao,
  • Qi Sun,
  • Zehua Wu,
  • Rui Ding,
  • Kun Zhou,
  • Gang He,
  • Yueyan Zhang

摘要

Bacterial infections seriously jeopardize human life and health. Photodynamic therapy (PDT), as an emerging noninvasive antibacterial strategy, has proven to be an effective treatment method against bacterial resistance. However, current photosensitizers suffer from inadequate free radical generation and limited functionality. To address this issue, a new π-conjugated viologen derivative, 3TPhDPyMeOTf, was designed. This derivative with multiple thiophene units enhances visible light absorption, and the presence of multiple pyridine structures allows the photosensitizer to generate more free radicals. Experimental and theoretical studies have demonstrated its inhibitory effect on bacterial growth both in vitro and in vivo, demonstrating a broad-spectrum antibacterial effect. The photosensitizer also exhibits excellent bacterial membrane staining, making it suitable for bacterial imaging. The design of this photosensitizer provides a new direction for the development of potent photosensitizers and photodynamic therapy.