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<p>Addressing the challenge of multidrug-resistant (MDR) bacteria is crucial for effective treatment of bacterial infections. This study aims to develop a novel antibacterial approach that is both safe and highly effective by incorporating metal-based nanoparticles into an acid-sensitive dynamic hydrogel. The resulting nanocomposite hydrogel (ACP@Ag/OC) demonstrates an impressive photothermal conversion efficiency (29.4%) and antioxidant capability. <i>In vitro</i> antibacterial tests indicate that this hydrogel exhibits a remarkable antibacterial activity against <i>Escherichia coli</i> (<i>E. coli</i>) (60%) and <i>Staphylococcus aureus</i> (<i>S. aureus</i>) (57%) due to the encapsulated metal-based nanoparticles. Notably, under near-infrared (NIR) irradiation, the antibacterial effectiveness increases by 1.7 times for both <i>S. aureus</i> and <i>E. coli</i>. Furthermore, in the presence of polydopamine, ACP@Ag/OC shows exceptional adhesion properties, even in strong water currents. Antioxidant tests reveal the nanocomposite hydrogel’s outstanding ability to scavenge reactive oxygen species. Hemolysis assays confirm that the ACP@Ag/OC hydrogel has excellent cytotoxicity and compatibility with blood. Thus, this delicate design paves the way for the development of a nanocomposite hydrogel for fighting bacterial infections even for use as a wound healing patch.</p>

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NIR-responsive nano-photothermal and antioxidant platforms to combat bacteria

  • 期刊论文

  • 发表日期：

    2025年5月12日

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  • Yuxiang Liu,
  • Dongrun Yu,
  • Hongyun Han,
  • Huizhen Jia

摘要

Addressing the challenge of multidrug-resistant (MDR) bacteria is crucial for effective treatment of bacterial infections. This study aims to develop a novel antibacterial approach that is both safe and highly effective by incorporating metal-based nanoparticles into an acid-sensitive dynamic hydrogel. The resulting nanocomposite hydrogel (ACP@Ag/OC) demonstrates an impressive photothermal conversion efficiency (29.4%) and antioxidant capability. In vitro antibacterial tests indicate that this hydrogel exhibits a remarkable antibacterial activity against Escherichia coli (E. coli) (60%) and Staphylococcus aureus (S. aureus) (57%) due to the encapsulated metal-based nanoparticles. Notably, under near-infrared (NIR) irradiation, the antibacterial effectiveness increases by 1.7 times for both S. aureus and E. coli. Furthermore, in the presence of polydopamine, ACP@Ag/OC shows exceptional adhesion properties, even in strong water currents. Antioxidant tests reveal the nanocomposite hydrogel’s outstanding ability to scavenge reactive oxygen species. Hemolysis assays confirm that the ACP@Ag/OC hydrogel has excellent cytotoxicity and compatibility with blood. Thus, this delicate design paves the way for the development of a nanocomposite hydrogel for fighting bacterial infections even for use as a wound healing patch.