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<p>Photothermal therapy (PTT) circumvents the constraints of conventional treatments and has manifested substantial potential for clinical applications. Nevertheless, the up-regulation of heat shock proteins (HSP) and mitochondria-encoded genes within tumor cells endows them with a high level of heat resistance, thereby limiting the ultimate efficacy of PTT. Herein, PtRhMo/Rh multi-metal-based nanozymes were designed by a one-step method for PTT and cascade enzymatic therapy. The PtRhMo/Rh nanozymes are capable of combining multiple enzymatic activities (catalase, oxidase, glutathione peroxidase, NADH oxidase and peroxidase) for reactive oxygen radical boosting. With the help of the near-infrared laser, PtRhMo/Rh nanozymes can not only kill tumor cells directly, but also down-regulate HSP70 level and destroy the mitochondrial to weaken the heat-resistant ability of tumor cells, further enhancing the effect of PTT. Overall, our work highlights a synergistic strategy for enzymatic therapy and enhanced PTT.</p>

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One-step synthesis of PtRhMo/Rh nanozymes for mitochondrial damage-mediated photothermal/enzymatic therapy

  • 期刊论文

  • 发表日期：

    2025年4月8日

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  • Danyang Li,
  • Enna Ha,
  • Yaoyao Zhu,
  • Shuqing He,
  • Shaolong Kuang,
  • Junqing Hu

摘要

Photothermal therapy (PTT) circumvents the constraints of conventional treatments and has manifested substantial potential for clinical applications. Nevertheless, the up-regulation of heat shock proteins (HSP) and mitochondria-encoded genes within tumor cells endows them with a high level of heat resistance, thereby limiting the ultimate efficacy of PTT. Herein, PtRhMo/Rh multi-metal-based nanozymes were designed by a one-step method for PTT and cascade enzymatic therapy. The PtRhMo/Rh nanozymes are capable of combining multiple enzymatic activities (catalase, oxidase, glutathione peroxidase, NADH oxidase and peroxidase) for reactive oxygen radical boosting. With the help of the near-infrared laser, PtRhMo/Rh nanozymes can not only kill tumor cells directly, but also down-regulate HSP70 level and destroy the mitochondrial to weaken the heat-resistant ability of tumor cells, further enhancing the effect of PTT. Overall, our work highlights a synergistic strategy for enzymatic therapy and enhanced PTT.