Self-adhesive ultrasound-mediated triboelectric nanogenerator device for subcutaneous antibacterial treatment and accelerated wound healing

Electrical stimulation therapy has excellent potential for wound healing and tissue regeneration. However, conventional approaches often require external power sources and implantable electrodes, which can limit their practical applications. Herein, we report the development of an ultrasound-mediated powered wound healing device (LH-TENG) that employs skin-adhesive AgC@L-g-PAM/HPC hydrogel as electrodes instead of traditional ones. Under ultrasound excitation, the LH-TENG can firmly adhere to tissue surfaces and generate a uniform electric field around the wound area, promoting cell migration, proliferation, and accelerating healing. Notably, the device exhibits antibacterial properties, making it promising for treating infected chronic wounds. Due to its wireless power supply, simple structure, and excellent biocompatibility, this ultrasound-mediated wound healing device has the potential and advantages of developing implantable therapy devices for treating infected chronic wounds.