In this paper we introduce and examine the differential subordinations related to the geometric mean of the form \(\begin{aligned} p(z)\left[ 1+\frac{zp'(z)}{p(z)}\varphi \left( p(z),zp'(z)\right) \right] ^\gamma \prec h(z),\quad z\in \mathbb D, \end{aligned}\) where \(\mathbb D:=\{z\in \mathbb C:|z|<1\}\) , h is a convex univalent function with \(0\in h(\mathbb D)\) , and with appropriate assumptions on \(\varphi \) and p. Proofs of main results are based on the original results and offer a new approach in the theory. In particular, the above differential subordination generalizes the well-known Briot-Bouquet differential subordination. Based on Loewner’s theory, the problem of the best dominant is discussed. Relevant applications within GFT are indicated.