Let \(\Phi \) be a locally integrable function, s be a measurable function on \(\mathbb {R}^+\) . Then the generalized Hausdorff operator, associated to the parameter curves \(s(x,t):=s(t)x\) , is defined by \(\mathcal {H}_{\Phi ,s}f(x)=\int _{\mathbb {R}^n}\frac{\Phi (y)}{|y|^n}f( s(|y|)x )dy. \) In this paper, we estabilish the boundedness of the generalized Hausdorff operators \(\mathcal {H}_{\Phi ,s}\) on mixed radial-angular central Morrey spaces. Moreover, we also obtain sufficient and necessary conditions on \(\Phi \) which ensure the boundedness of their commutators on mixed radial-angular central Morrey spaces with symbols in mixed radial-angular central BMO spaces.