We provide novel lower bounds on the Betti numbers of Vietoris–Rips complexes of hypercube graphs of all dimensions and at all scales. In more detail, let \(Q_n\) be the vertex set of \(2^n\) vertices in the n-dimensional hypercube graph, equipped with the shortest path metric. Let \(\textrm{VR}(Q_n;r)\) be its Vietoris–Rips complex at scale parameter \(r \ge 0\) , which has \(Q_n\) as its vertex set, and all subsets of diameter at most r as its simplices. For integers \(r<r'\) the inclusion \(\textrm{VR}(Q_n;r)\hookrightarrow \textrm{VR}(Q_n;r')\) is nullhomotopic, meaning no persistent homology bars have length longer than one, and we therefore focus attention on the individual spaces \(\textrm{VR}(Q_n;r)\) . We provide lower bounds on the ranks of homology groups of \(\textrm{VR}(Q_n;r)\) . For example, using cross-polytopal generators, we prove that the rank of \(H_{2^r-1}(\textrm{VR}(Q_n;r))\) is at least \(2^{n-(r+1)}\left( {\begin{array}{c}n\\ r+1\end{array}}\right) \) . We also prove a version of homology propagation: if \(q\ge 1\) and if p is the smallest integer for which \(\textrm{rank}H_q(\textrm{VR}(Q_p;r))\ne 0\) , then \(\textrm{rank}H_q(\textrm{VR}(Q_n;r)) \ge \sum _{i=p}^n 2^{i-p} \left( {\begin{array}{c}i-1\\ p-1\end{array}}\right) \cdot \textrm{rank}H_q(\textrm{VR}(Q_p;r))\) for all \(n \ge p\) . When \(r\le 3\) , this result and variants thereof provide tight lower bounds on the rank of \(H_q(\textrm{VR}(Q_n;r))\) for all n, and for each \(r \ge 4\) we produce novel lower bounds on the ranks of homology groups. Furthermore, we show that for each \(r\ge 2\) , the homology groups of \(\textrm{VR}(Q_n;r)\) for \(n \ge 2r+1\) contain propagated homology not induced by the initial cross-polytopal generators.