<p>Zinc leach residue (ZLR) is a metallurgical waste with economic value because it contains a significant amount of valuable metals. This type of waste also poses a risk to environmental health. The present paper describes the recovery of lead and zinc from ZLR with choline chloride (ChCl)-based deep eutectic solvent via solvometallurgical routes including leaching, cementation, and hydrolysis. Characterization studies showed that the ZLR consists of Pb, Zn, Fe, Si, and Ca in different proportions. Additionally, the mineralogical analysis revealed that ZLR has a complex structure and contains various phases such as PbSO₄, Zn₂SiO₄, and ZnFe₂O₄. After leaching experiments, the highest extraction yields were obtained as 81.44% Pb and 31.95% Zn under optimum condition as 1&#xa0;h leaching duration, 75&#xa0;°C leaching temperature, and 1/40&#xa0;g/mL solid/liquid ratio. Lead was obtained in metallic form with 90% efficiency by the cementation method using zinc powder. Finally, the zinc oxide particles with an average size of 3 µm were produced from zinc-rich solution with hydrolysis. The suggested approach is shown to be a promising route for the recovery of lead and zinc from the ZLR with environmentally friendly and low energy requirements.</p> Graphical Abstract <p></p>