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<p>Hydrogels derived from biopolymers have numerous applications in bioengineering, drug delivery, wound healing, and wearable devices. Yet, their strong swelling and uncontrollable degradation stimulate the development of hydrogels that overcome these limitations. Here, we report nanocolloidal hydrogels formed from nanoparticles of methacryloyl-modified biopolymers that exhibit resistance to swelling and enzymatic degradation both in vitro and in vivo, along with exhibiting a broad-range of mechanical and lubrication properties, wear resistance and biocompatibility. The nonswelling behavior of nanocolloidal hydrogels takes origin in the resistance to swelling of their hydrophobic regions which are resulted from the nanophase of hydrophobic methacryloyl groups in the interior of the constituent nanoparticles. The developed approach to the preparation of nanocolloidal hydrogel with greatly enhanced properties will have applications in long-term drug delivery and cell culture, soft tissue augmentation, and implantable bioelectronics.</p><p></p>

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Nonswelling Lubricative Nanocolloidal Hydrogel Resistant to Biodegradation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月11日

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  • Tiantian Ding,
  • Chunxia Ren,
  • Liyuan Meng,
  • Guoyong Han,
  • Yao Xue,
  • Wenlong Song,
  • Daowei Li,
  • Hongchen Sun,
  • Bai Yang,
  • Yunfeng Li

摘要

Hydrogels derived from biopolymers have numerous applications in bioengineering, drug delivery, wound healing, and wearable devices. Yet, their strong swelling and uncontrollable degradation stimulate the development of hydrogels that overcome these limitations. Here, we report nanocolloidal hydrogels formed from nanoparticles of methacryloyl-modified biopolymers that exhibit resistance to swelling and enzymatic degradation both in vitro and in vivo, along with exhibiting a broad-range of mechanical and lubrication properties, wear resistance and biocompatibility. The nonswelling behavior of nanocolloidal hydrogels takes origin in the resistance to swelling of their hydrophobic regions which are resulted from the nanophase of hydrophobic methacryloyl groups in the interior of the constituent nanoparticles. The developed approach to the preparation of nanocolloidal hydrogel with greatly enhanced properties will have applications in long-term drug delivery and cell culture, soft tissue augmentation, and implantable bioelectronics.