<p>Climate change is a global concern and global efforts are being made to reduce the presence of carbon dioxide in the atmosphere. This study investigated carbon dioxide removal impact on heat/cold waves and heat stress conditions in West Africa using UKESM1 and CNRM-ESM1-C1 Carbon Dioxide Removal Model Intercomparison Project (CDRMIP) simulation outputs. Understanding this impact is important due to the region’s vulnerability to climate change and its dependence on climate-sensitive sectors such as agriculture and public health. Three indices – Effective Temperature Index (ETI), Humidex Index (HD) and Temperature Humidity Index (THI) were used to evaluate heat stress in each of the periods – 1990–2019 (reference), 2040–2069, 2070–2099 and 2100–2129 since they have humidity term and hence, can give a comprehensive description of the climate scenario over West Africa. Excess heat factor (EHF) index was used to evaluate heat/cold wave. The three indices projected heat stress over West Africa within thermal comfort limit. 80.3% of the total number of days analyzed in Sahel regions were within the range of normal days. On the average, 7665 normal days were projected over West Africa at 95^th and 5^th percentile daily mean temperatures (reference period) of 39.2°C and 25.3°C, respectively, in the period 2070-2099. There were 3135 cold days with no “severe” intensity. The analyses revealed predominance of cold wave and reduction in daily mean temperature before the end of 21^st century, indicating the potentials of CDR in ameliorating the prevailing heatwave over West Africa.</p>