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Introduction <p>Psoriatic arthritis (PsA) is a complex inflammatory disease often associated with metabolic syndrome (MetS). It has been demonstrated that pain catastrophizing (PC), characterized by an exaggerated negative cognitive and emotional response to actual or anticipated pain, impacts the achievement of remission and therapy discontinuation in patients with PsA. In this study, we evaluate the potential role of MetS, the most prevalent comorbidity in PsA, in influencing PC in patients with PsA.</p> Methods <p>We conducted a cross-sectional, observational study on 170 patients with PsA who met the Classification Criteria for PsA and MetS criteria. Data on disease activity, PC, and comorbidities were collected and analyzed using univariable and multivariable regressions.</p> Results <p>Our results indicate a significant association between MetS and elevated PC levels in patients with PsA. Univariable analysis identified female gender, fibromyalgia, and higher Disease Activity for Psoriatic Arthritis (DAPSA) scores as factors associated with increased PC. Multivariable analysis, adjusted for age, sex, fibromyalgia, and DAPSA, confirmed that MetS independently correlates with higher PC levels (<i>b</i> = 8.84, 95% CI 4.66–13.02, <i>p</i> &lt; 0.0001) and its domains (helplessness, rumination, magnification).</p> Conclusions <p>These findings suggest that MetS significantly impacts PC in PsA, underscoring the need for a multidisciplinary approach to patient management. This study highlights the importance of addressing MetS to reduce pain catastrophizing and enhance disease management in PsA.</p>

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The Relationship Between Metabolic Syndrome and Pain Catastrophizing in Psoriatic Arthritis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月26日

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  • Damiano Currado,
  • Onorina Berardicurti,
  • Francesca Saracino,
  • Francesca Trunfio,
  • Lyubomyra Kun,
  • Annalisa Marino,
  • Erika Corberi,
  • Ludovica Lamberti,
  • Piero Ruscitti,
  • Vasiliki Liakouli,
  • Marta Vadacca,
  • Amelia Rigon,
  • Luisa Arcarese,
  • Manuela Pietramale,
  • Francesco De Vincenzo,
  • Marta Vomero,
  • Francesco Ciccia,
  • Roberto Giacomelli,
  • Luca Navarini

摘要

Introduction

Psoriatic arthritis (PsA) is a complex inflammatory disease often associated with metabolic syndrome (MetS). It has been demonstrated that pain catastrophizing (PC), characterized by an exaggerated negative cognitive and emotional response to actual or anticipated pain, impacts the achievement of remission and therapy discontinuation in patients with PsA. In this study, we evaluate the potential role of MetS, the most prevalent comorbidity in PsA, in influencing PC in patients with PsA.

Methods

We conducted a cross-sectional, observational study on 170 patients with PsA who met the Classification Criteria for PsA and MetS criteria. Data on disease activity, PC, and comorbidities were collected and analyzed using univariable and multivariable regressions.

Results

Our results indicate a significant association between MetS and elevated PC levels in patients with PsA. Univariable analysis identified female gender, fibromyalgia, and higher Disease Activity for Psoriatic Arthritis (DAPSA) scores as factors associated with increased PC. Multivariable analysis, adjusted for age, sex, fibromyalgia, and DAPSA, confirmed that MetS independently correlates with higher PC levels (b = 8.84, 95% CI 4.66–13.02, p < 0.0001) and its domains (helplessness, rumination, magnification).

Conclusions

These findings suggest that MetS significantly impacts PC in PsA, underscoring the need for a multidisciplinary approach to patient management. This study highlights the importance of addressing MetS to reduce pain catastrophizing and enhance disease management in PsA.