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<p>In the present study, the natural product eugenol was chemically modified to develop a series of anticorrosive and antimicrobial derivatives. These compounds were synthesized in high yields (70–96%) and fully characterized by FTIR spectroscopy, as well as by ¹H and ¹³C. The anticorrosive properties of these compounds were first investigated on carbon steel in 1&#xa0;M HCl using potentiodynamic polarization and electrochemical impedance spectroscopy (EIS). Electrochemical measurements revealed that all synthesized derivatives behaved as mixed-type corrosion inhibitors, as indicated by the small shifts in corrosion potential (|ΔEcorr| &lt; 85 mV). The corrosion current density markedly decreased from 322.8 to 12.8 µA·cm⁻² upon the addition of 10⁻³ M of inhibitor, demonstrating strong adsorption onto the metal surface and the formation of a protective film. Inhibition efficiencies approached 90% over the studied temperature range, and long-term protection was further confirmed by immersion tests. In parallel, the antimicrobial performance of the derivatives was assessed against clinically relevant pathogenic strains, including <i>S. aureus</i>,<i> E. coli</i>,<i> K. pneumoniae</i>,<i> P. mirabilis</i>,<i> and P. aeruginosa</i>. Several compounds exhibited notable antibacterial activity, producing inhibition zones greater than 11&#xa0;mm at 100&#xa0;µg·mL⁻¹. Overall, the newly synthesized eugenol derivatives exhibit dual functionality, acting as highly effective corrosion inhibitors in acidic environments and as promising antibacterial agents, underscoring their potential for industrial and biomedical applications.</p>

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Valorisation of an Aromatic Compound from a Renewable Natural Resource: Eugenol, by Hemi-synthesis of New Molecules for Antimicrobial and Anticorrosion Applications

  • 期刊论文

  • 发表日期：

    2026年5月19日

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  • Bahija Rebbah,
  • Abderrahim El haib,
  • Sara Lahmady,
  • Yassine Aallam,
  • Wissal Kotmani,
  • Rachid Hnini,
  • Maryse Gouygou,
  • Issam Forsal,
  • ElMostapha Rakib,
  • Abdellah Hannioui

摘要

In the present study, the natural product eugenol was chemically modified to develop a series of anticorrosive and antimicrobial derivatives. These compounds were synthesized in high yields (70–96%) and fully characterized by FTIR spectroscopy, as well as by ¹H and ¹³C. The anticorrosive properties of these compounds were first investigated on carbon steel in 1 M HCl using potentiodynamic polarization and electrochemical impedance spectroscopy (EIS). Electrochemical measurements revealed that all synthesized derivatives behaved as mixed-type corrosion inhibitors, as indicated by the small shifts in corrosion potential (|ΔEcorr| < 85 mV). The corrosion current density markedly decreased from 322.8 to 12.8 µA·cm⁻² upon the addition of 10⁻³ M of inhibitor, demonstrating strong adsorption onto the metal surface and the formation of a protective film. Inhibition efficiencies approached 90% over the studied temperature range, and long-term protection was further confirmed by immersion tests. In parallel, the antimicrobial performance of the derivatives was assessed against clinically relevant pathogenic strains, including S. aureus, E. coli, K. pneumoniae, P. mirabilis, and P. aeruginosa. Several compounds exhibited notable antibacterial activity, producing inhibition zones greater than 11 mm at 100 µg·mL⁻¹. Overall, the newly synthesized eugenol derivatives exhibit dual functionality, acting as highly effective corrosion inhibitors in acidic environments and as promising antibacterial agents, underscoring their potential for industrial and biomedical applications.