Purpose of Review <p>Effective management of aquaculture wastewater is essential for maintaining ecosystem health, ensuring the safety of aquatic products, and protecting human health. Despite advancements in aquaculture practices and wastewater treatment technologies, a comprehensive review addressing the risks associated with various pollutants is lacking. This review aims to fill that gap by examining the risks and regeneration technologies related to aquaculture wastewater.</p> Recent Findings <p>This systematic review analyzes the risk profiles of different pollutants in aquaculture wastewater, highlighting the complexity of these contaminants. It reviews the characteristics and mechanisms of physical, chemical, and biological regeneration technologies employed in wastewater treatment. The findings indicate that the sources, composition, and hazardous properties of key pollutants vary, and the existing reuse technologies provide differing treatment advantages.</p> Summary <p>The review identifies limitations in current treatment methods and proposes future research directions, emphasizing the need to investigate the synergistic effects of pollutants, particularly emerging contaminants. It also suggests establishing clear criteria for acceptable contaminant levels and optimizing integrated treatment approaches. These insights will enhance aquaculture wastewater management and contribute to the sustainable development of the aquaculture industry.</p> Graphical Abstract <p></p>