Purpose of Review <p>Sleep disturbances are common in individuals with gastrointestinal (GI) disorders. The connection between sleep and GI symptoms is bidirectional and influenced by shared biopsychosocial mechanisms and cognitive-behavioral factors, including alterations in the stress response. Treating sleep disturbances can effectively manage coexisting symptoms. This review explores current research on sleep treatments for GI conditions, emphasizing mind-body interventions that target stress.</p> Recent Findings <p>Both pharmacological and non-pharmacological approaches (e.g., cognitive behavioral therapy for insomnia) benefit patients with sleep disturbance and concomitant GI symptoms; however, they have limitations. Other approaches, including mind-body interventions, may improve sleep quality, reduce GI symptoms, and enhance quality of life. </p> Summary <p>Mind-body interventions can complement other evidence-based approaches for patients with co-morbid sleep disturbance and GI symptoms. However, more rigorous research is warranted to fully understand their benefit. As research evolves, healthcare professionals can guide patients on how to best integrate these approaches into their care.</p>